An update on randomized clinical trials in advanced and metastatic colorectal carcinoma Journal Article
| Authors: | Maithel, S. K.; D'Angelica, M. I. |
| Article Title: | An update on randomized clinical trials in advanced and metastatic colorectal carcinoma |
| Abstract: | During the past eight years, there have been significant advances in the treatment and outcome of patients with metastatic colorectal cancer. This is likely the result of improved imaging, staging, chemotherapy, and surgery. After conducting a standardized MEDLINE literature search, this article reviews the prospective randomized controlled trials in advanced colorectal cancer published between May 2001 and October 2008. There are a total of 96 studies, all chemotherapy-related trials, divided into five categories based on trial focus: (1) types of chemotherapy; (2) administration of adjuvant or neoadjuvant chemotherapy for resectable liver metastases; (3) regional chemotherapy with hepatic arterial infusion; (4) molecular markers of chemotherapy efficacy; and (5) duration, dosing, and sequencing of chemotherapy. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; protein expression; treatment outcome; clinical trial; neutropenia; review; bevacizumab; fluorouracil; placebo; advanced cancer; cancer combination chemotherapy; diarrhea; drug dose reduction; drug efficacy; drug safety; hypertension; monotherapy; treatment duration; unspecified side effect; liver neoplasms; capecitabine; cancer adjuvant therapy; cancer radiotherapy; chemotherapy; methotrexate; bolus injection; low drug dose; metastasis; controlled clinical trial; drug eruption; multiple cycle treatment; sensory neuropathy; gastrointestinal symptom; nausea; randomized controlled trial; thrombocytopenia; vomiting; dehydration; epidermal growth factor receptor; randomized controlled trials as topic; cetuximab; irinotecan; colorectal carcinoma; febrile neutropenia; colorectal neoplasms; liver metastasis; randomized controlled trials; celecoxib; folinic acid; drug response; liver resection; mitomycin c; oxaliplatin; k ras protein; hand foot syndrome; alopecia; repeated drug dose; granulocytopenia; marimastat; carbamazepine; liver metastases; metastatic colorectal cancer |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-01-01 |
| Start Page: | 163 |
| End Page: | 181 |
| Language: | English |
| DOI: | 10.1016/j.soc.2009.09.013 |
| PUBMED: | 19914565 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: SOCAF" - "Source: Scopus" |
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