Randomized clinical trials in rectal and anal cancers Journal Article
| Authors: | Park, J.; Neuman, H. B.; Weiser, M. R.; Wong, W. D. |
| Article Title: | Randomized clinical trials in rectal and anal cancers |
| Abstract: | This article reviews randomized clinical trials (RCTs) published between April 2001 and November 2008 on the management of patients with rectal cancer. In total, the authors reviewed 78 RCTs on therapy for rectal cancer. Of these, five met the authors' criteria for level 1a evidence. The article discusses the major RCTs and relevant findings that have impacted clinical management most and includes most but not all RCTs on therapy for rectal cancer published during this period. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; treatment outcome; surgical technique; clinical trial; review; cisplatin; fluorouracil; cancer combination chemotherapy; drug efficacy; monotherapy; multimodality cancer therapy; unspecified side effect; cancer adjuvant therapy; cancer radiotherapy; chemotherapy; antineoplastic agent; laparoscopic surgery; bolus injection; controlled clinical trial; multiple cycle treatment; radiation; blood toxicity; randomized controlled trial; randomized controlled trials as topic; continuous infusion; folinic acid; drug response; stoma; surgery; intermethod comparison; mitomycin c; minimally invasive surgery; anus cancer; rectal neoplasms; rectum cancer; rectum surgery; rectal cancer; tegafur; colostomy; rectum anterior resection; rectum abdominoperineal resection; anastomosis leakage; anoplasty; anal cancer; randomized trials; uracil; preoperative radiotherapy; anus neoplasms |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-01-01 |
| Start Page: | 205 |
| End Page: | 223 |
| Language: | English |
| DOI: | 10.1016/j.soc.2009.09.005 |
| PUBMED: | 19914567 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: SOCAF" - "Source: Scopus" |
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