Signalling change: Signal transduction through the decades Journal Article
| Authors: | Hynes, N. E.; Ingham, P. W.; Lim, W. A.; Marshall, C. J.; Massague, J.; Pawson, T. |
| Article Title: | Signalling change: Signal transduction through the decades |
| Abstract: | The past few years have marked significant anniversaries in signal transduction, including the identification of classic growth factors and morphogens, the notion of protein modification through phosphorylation and the characterization of protein interaction domains. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades. © 2013 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; mitogen activated protein kinase; platelet derived growth factor; vasculotropin; protein expression; protein phosphorylation; oncoprotein; gene mutation; review; genetic analysis; protein domain; neoplasm; cell proliferation; mass spectrometry; protein analysis; breast cancer; basal cell carcinoma; bone morphogenetic protein; transforming growth factor beta; epidermal growth factor receptor; epidermal growth factor receptor 2; fluorescence; in vivo study; cell differentiation; protein tyrosine kinase; chronic myeloid leukemia; proteomics; cetuximab; phosphatidylinositol 3 kinase; prediction; immunology; dna; protein purification; epigenetics; fibroblast; cytoplasm; innate immunity; dna sequence; dimerization; ras protein; feedback system; drosophila melanogaster; bcr abl protein; catalysis; negative feedback; molecular biology; trastuzumab; ex vivo study; biochemistry; guanine nucleotide binding protein; b raf kinase; toll like receptor; fibroblast growth factor; scientist; protein modification; pertuzumab; professional knowledge; vismodegib; nerve growth factor |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 14 |
| Issue: | 6 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-06-01 |
| Start Page: | 393 |
| End Page: | 398 |
| Language: | English |
| DOI: | 10.1038/nrm3581 |
| PROVIDER: | scopus |
| PUBMED: | 23636498 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 July 2013" - "CODEN: NRMCB" - "Source: Scopus" |
