TGF-β signal transduction Journal Article
| Author: | Massagué, J. |
| Article Title: | TGF-β signal transduction |
| Abstract: | The transforming growth factor β (TGF-β) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF- β signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-β and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders. |
| Keywords: | signal transduction; gene mutation; dna-binding proteins; review; nonhuman; protein localization; neoplasms; cell proliferation; smad1 protein; transforming growth factor beta; drosophila; cell specificity; gene expression regulation; protein-serine-threonine kinases; receptors, transforming growth factor beta; development; trans-activators; protein family; homeostasis; structure analysis; ligand binding; biological transport; tgf-β; metazoon; genetic diseases, inborn; growth factors; cancer; humans; priority journal; receptor serine/threonine kinases; smads |
| Journal Title: | Annual Review of Biochemistry |
| Volume: | 67 |
| ISSN: | 0066-4154 |
| Publisher: | Annual Reviews |
| Date Published: | 1998-07-01 |
| Start Page: | 753 |
| End Page: | 791 |
| Language: | English |
| DOI: | 10.1146/annurev.biochem.67.1.753 |
| PUBMED: | 9759503 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 12 December 2016 -- Source: Scopus |
