Immune response to premalignancy: Insights from patients with monoclonal gammopathy Conference Paper
| Author: | Dhodapkar, M. V. |
| Title: | Immune response to premalignancy: Insights from patients with monoclonal gammopathy |
| Conference Title: | Human Immunology: Patient-Based Research |
| Abstract: | Many patients with preneoplastic gammopathy remain clinically stable, in spite of the presence of multiple genomic abnormalities in tumor cells. Our hypothesis is that the development of clinical cancer depends not just on the genomic changes in tumor cells, but also their interactions with the host-tumor microenvironment. Recent studies have shown that the host immune system is capable of responding to preneoplastic cells. Improved understanding of this response may provide novel opportunities for early detection and immune prevention of cancer. |
| Keywords: | inflammation; dendritic cells; antigens; lymphocytes; myeloma; multiple-myeloma; prevention; bone-marrow; killer t-cells; cross-presentation; plasma-cells; undetermined significance |
| Journal Title | Annals of the New York Academy of Sciences |
| Volume: | 1062 |
| Conference Dates: | 2005 May 16-18 |
| Conference Location: | New York, NY |
| ISBN: | 0077-8923 |
| Publisher: | John Wiley & Sons |
| Location: | New York |
| Date Published: | 2005-12-01 |
| Start Page: | 22 |
| End Page: | 28 |
| Language: | English |
| ACCESSION: | WOS:000236473100003 |
| PROVIDER: | wos |
| PUBMED: | 16461785 |
| DOI: | 10.1196/annals.1358.004 |
| Notes: | - Article; Proceedings Paper in "Human Immunology: Patient-Based Research" - Conference on Human Immunology - MAY 16-18, 2005 - New York, NY - NY Acad Sci, Dana Fdn - 2 EAST 63RD ST, NEW YORK, NY 10021 USA - "Source: Wos" |
