Harnessing host immune responses to preneoplasia: Promise and challenges Journal Article
| Author: | Dhodapkar, M. V. |
| Article Title: | Harnessing host immune responses to preneoplasia: Promise and challenges |
| Abstract: | Preneoplastic lesions are more common than clinical cancer and define a population at increased risk for the development of malignancy. Recent studies suggest that the immune system has the capacity to recognize these lesions, and enrichment of preneoplasia-specific immune effectors can be detected in the tumor bed of some preneoplastic lesions such as monoclonal gammopathies. Here, I discuss the promise and challenges of harnessing the immune response against preneoplasia. Approaches to boost the natural host response to these lesions may have a major impact on reducing net cancer burden. © Springer-Verlag 2004. |
| Keywords: | cancer risk; neoplasm; neoplasms; animals; immune system; carcinogenesis; models, animal; immune response; antigens, neoplasm; cancer vaccines; tumor immunity; monoclonal immunoglobulinemia; myeloma; precancerous conditions; prevention; immunologic surveillance; gammopathy |
| Journal Title: | Cancer Immunology, Immunotherapy |
| Volume: | 54 |
| Issue: | 5 |
| ISSN: | 0340-7004 |
| Publisher: | Springer |
| Date Published: | 2005-05-01 |
| Start Page: | 409 |
| End Page: | 413 |
| Language: | English |
| DOI: | 10.1007/s00262-004-0607-8 |
| PUBMED: | 15602654 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 24 October 2012" - "CODEN: CIIMD" - "Source: Scopus" |
