Vigorous premalignancy-specific effector T cell response in the bone marrow of patients with monoclonal gammopathy Journal Article
| Authors: | Dhodapkar, M. V.; Krasovsky, J.; Osman, K.; Geller, M. D. |
| Article Title: | Vigorous premalignancy-specific effector T cell response in the bone marrow of patients with monoclonal gammopathy |
| Abstract: | Most approaches targeting the immune system against tumors have focused on patients with established tumors. However, whether the immune system can recognize preneoplastic stages of human cancer is not known. Here we show that patients with preneoplastic gammopathy mount a vigorous T cell response to autologous premalignant cells. This preneoplasia-specific CD4 + and CD8 + T cell response is detected in freshly isolated T cells from the BM. T cells from myeloma marrow lack this tumor-specific rapid effector function. These data provide direct evidence for tumor specific immune recognition in human preneoplasia and suggest a possible role for the immune system in influencing the early growth of transformed cells, long before the development of clinical cancer. |
| Keywords: | clinical article; controlled study; human tissue; human cell; flow cytometry; cd8 antigen; t lymphocyte; t-lymphocytes; bone marrow cells; cancer prevention; immune system; multiple myeloma; bone marrow; dendritic cell; carcinogenesis; dendritic cells; immune response; cell transformation; cell isolation; effector cell; cd4 antigen; tumor growth; monoclonal immunoglobulinemia; t lymphocyte subpopulation; vaccine; myeloma; precancerous conditions; prevention; tumor immunology; precancer; paraproteinemias; interferon type ii; gammopathy; humans; human; priority journal; article |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 198 |
| Issue: | 11 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2003-12-01 |
| Start Page: | 1753 |
| End Page: | 1757 |
| Language: | English |
| DOI: | 10.1084/jem.20031030 |
| PUBMED: | 14638846 |
| PROVIDER: | scopus |
| PMCID: | PMC2194131 |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
