Genitourinary cancer predisposition syndromes Journal Article
| Authors: | Gallagher, D. J.; Feifer, A.; Coleman, J. A. |
| Article Title: | Genitourinary cancer predisposition syndromes |
| Abstract: | Despite epidemiologic data supporting a significant genetic contribution to the cause of genitourinary malignancies, their diagnosis rarely results in clinical genetics referral and the heritability of prostate, bladder, kidney, and testicular cancer remains poorly understood. Little of this inheritance has been explained by rare, high-penetrance predisposition syndromes and, although rare genetic variation may explain some of the remaining familial predisposition, recent genome-wide association studies support an important causal role for more common genomic variation and other structural variants. Susceptibility loci associated with risk of prostate, bladder, and testicular cancer have been identified that may improve our understanding of the cause and natural history of these malignancies. It remains to be seen whether this emerging knowledge of genetic predisposition can meaningfully contribute to the clinical management of genitourinary malignancies. © 2010 Elsevier Inc. |
| Keywords: | review; cancer risk; cancer incidence; cancer susceptibility; heredity; genetic predisposition to disease; gene locus; genetic association; genetic variability; gene frequency; brca1 protein; brca2 protein; bladder cancer; urogenital tract cancer; urinary bladder neoplasms; kidney neoplasms; prostate cancer; urogenital neoplasms; prostatic neoplasms; nephron sparing surgery; testicular neoplasms; glutathione transferase; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; urogenital tract tumor; hereditary leiomyomatosis renal cell carcinoma; birt hogg dube syndrome; kidney cancer; von hippel lindau disease; testis cancer; arylamine acetyltransferase; germ cell tumor; transitional cell carcinoma; tuberous sclerosis; genetic testing; genetic linkage; genetic heterogeneity; sex cord tumor; genetic; genitourinary; predisposition; hereditary papillary renal cancer; neoplastic syndromes, hereditary |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | 861 |
| End Page: | 883 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2010.06.002 |
| PUBMED: | 20816578 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: HCNAE" - "Source: Scopus" |
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