Prostate cancer: Germline prediction for a commonly variable malignancy Journal Article
| Authors: | Bambury, R. M.; Gallagher, D. J. |
| Article Title: | Prostate cancer: Germline prediction for a commonly variable malignancy |
| Abstract: | OBJECTIVES Prostate cancer is a heterogeneous disease and biomarkers to predict its incidence and subsequent clinical behaviour are needed to tailor screening, prevention and therapeutic strategies. In this review we focus on the potential of germline genetic variation to provide these biomarkers. METHODS We review the published literature on germline genetics in prostate cancer and examine the possibility of including germline genetic biomarkers in future prostate cancer clinical trials. RESULTS Rare mutations in genes such as BRCA1, BRCA2 and HOXB13 can affect prostate cancer incidence and/or clinical behaviour. Genome-wide association studies (GWAS) have identified more common genetic variations that explain an estimated 20% of familial prostate cancer risk. Germline genetics may have a role in treatment selection, if reliable pharmacogenetic predictors of efficacy and toxicity can be identified. CONCLUSION This rapidly emerging area of prostate cancer research may provide answers to current clinical conundrums in the prostate cancer treatment paradigm. We have outlined possible mechanisms for including germline investigation in future prostate cancer clinical trial design. |
| Keywords: | prostate cancer; tamoxifen; molecular biology; therapy; endocrine therapy; breast-cancer; genome-wide association; high-risk; linkage analysis; brca mutation; susceptibility locus; androgen receptor gene; germline genetics; chromosome 1q42.2-43 |
| Journal Title: | BJU International |
| Volume: | 110 |
| Issue: | 11C |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2012-01-01 |
| Start Page: | E809 |
| End Page: | E818 |
| Language: | English |
| DOI: | 10.1111/j.1464-410X.2012.11450.x |
| ACCESSION: | WOS:000315029700004 |
| PROVIDER: | wos |
| Notes: | --- - Review - "Source: Wos" |
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