Genome-wide association studies of cancer Journal Article


Authors: Stadler, Z. K.; Thom, P.; Robson, M. E.; Weitzel, J. N.; Kauff, N. D.; Hurley, K. E.; Devlin, V.; Gold, B.; Klein, R. J.; Offit, K.
Article Title: Genome-wide association studies of cancer
Abstract: Knowledge of the inherited risk for cancer is an important component of preventive oncology. In addition to well-established syndromes of cancer predisposition, much remains to be discovered about the genetic variation underlying susceptibility to common malignancies. Increased knowledge about the human genome and advances in genotyping technology have made possible genome-wide association studies (GWAS) of human diseases. These studies have identified many important regions of genetic variation associated with an increased risk for human traits and diseases including cancer. Understanding the principles, major findings, and limitations of GWAS is becoming increasingly important for oncologists as dissemination of genomic risk tests directly to consumers is already occurring through commercial companies. GWAS have contributed to our understanding of the genetic basis of cancer and will shed light on biologic pathways and possible new strategies for targeted prevention. To date, however, the clinical utility of GWAS-derived risk markers remains limited.
Keywords: susceptibility; colorectal-cancer; prostate-cancer; lung-cancer; positive breast-cancer; basal-cell carcinoma; loci; common sequence variants; 5 genetic-variants; population stratification; confer susceptibility
Journal Title: Journal of Clinical Oncology
Volume: 28
Issue: 27
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2010-09-20
Start Page: 4255
End Page: 4267
Language: English
ACCESSION: ISI:000281909700024
DOI: 10.1200/jco.2009.25.7816
PROVIDER: wos
PMCID: PMC2953976
PUBMED: 20585100
Notes: --- - Review - "Source: Wos"
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MSK Authors
  1. Kenneth Offit
    507 Offit
  2. Mark E Robson
    365 Robson
  3. Noah Kauff
    122 Kauff
  4. Zsofia Kinga Stadler
    144 Stadler
  5. Karen E Hurley
    45 Hurley
  6. Robert J. Klein
    59 Klein
  7. Peter Thom
    6 Thom
  8. Vincent Devlin
    6 Devlin