Genome-wide association studies of cancer: Principles and potential utility Journal Article
| Authors: | Stadler, Z. K.; Gallagher, D. J.; Thom, P.; Offit, K. |
| Article Title: | Genome-wide association studies of cancer: Principles and potential utility |
| Abstract: | Genome-wide association studies (GWAS) have emerged as a new approach for investigating the genetic basis of complex diseases. In oncology, genome-wide studies of nearly all common malignancies have been performed and more than 100 genetic variants associated with increased risks have been identified. GWAS approaches are powerful research tools that are revealing novel pathways important in carcinogenesis and promise to further enhance our understanding of the basis of inherited cancer susceptibility. However, personal genomic tests based on cancer GWAS results that are currently being offered by for-profit commercial companies for cancer risk prediction have unproven clinical utility and may risk false conveyance of reassurance or alarm. |
| Keywords: | single nucleotide polymorphism; review; cancer risk; glioma; clinical practice; neoplasm; colorectal cancer; accuracy; allele; dna damage; cancer susceptibility; ovary cancer; breast cancer; basal cell carcinoma; genetic association; genetic variability; genotype; lung cancer; brca1 protein; brca2 protein; bladder cancer; prediction; carcinogenesis; prostate cancer; stomach cancer; validity; thyroid cancer; acute lymphocytic leukemia; disease predisposition; esophagus cancer; chronic lymphatic leukemia; genetic predisposition; germ cell tumor; follicular lymphoma; oncogene myc |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 24 |
| Issue: | 7 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2010-06-01 |
| Start Page: | 629 |
| End Page: | 637 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 20669800 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: OCLGE" - "Source: Scopus" |
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