Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer Journal Article

   


Authors: Hoffmann, T. J.; Passarelli, M. N.; Graff, R. E.; Emami, N. C.; Sakoda, L. C.; Jorgenson, E.; Habel, L. A.; Shan, J.; Ranatunga, D. K.; Quesenberry, C. P.; Chao, C. R.; Ghai, N. R.; Aaronson, D.; Presti, J.; Nordström, T.; Wang, Z.; Berndt, S. I.; Chanock, S. J.; Mosley, J. D.; Klein, R. J.; Middha, M.; Lilja, H.; Melander, O.; Kvale, M. N.; Kwok, P. Y.; Schaefer, C.; Risch, N.; Van Den Eeden, S. K.; Witte, J. S.
Article Title: Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
Abstract: Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa - such as genetics - can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P<5 × 10-8) single-nucleotide polymorphisms (SNPs): 19 novel, 15 previously identified for PSA (14 of which were also PCa-associated), and 6 previously identified for PCa only. Further analysis incorporating PCa cases suggests that at least half of the 40 SNPs are PSA-associated independent of PCa. The 40 SNPs explain 9.5% of PSA variation in non-Hispanic whites, and the remaining GWAS SNPs explain an additional 31.7%; this percentage is higher in younger men, supporting the genetic basis of PSA levels. These findings provide important information about genetic markers for PSA that may improve PCa screening, thereby reducing over-diagnosis and over-treatment. © The Author(s) 2017.
Journal Title: Nature Communications
Volume: 8
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2017-01-31
Start Page: 14248
Language: English
DOI: 10.1038/ncomms14248
PROVIDER: scopus
PMCID: PMC5290311
PUBMED: 28139693
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011317435&doi=10.1038%2fncomms14248&partnerID=40&md5=e037f65b994e4b8bc66447d02d16d85c
Notes: Article -- Export Date: 2 March 2017 -- Source: Scopus
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MSK Authors
  1. Hans Gosta Lilja
    345 Lilja
  2. Robert J. Klein
    63 Klein
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