Authors: | Callahan, M. K.; Kemeny, N. E. |
Article Title: | Implanted hepatic arterial infusion pumps |
Abstract: | Globally, the number of colorectal carcinoma-related deaths totals close to 600,000 each year, with metastatic disease representing the major cause of morbidity and mortality. The liver is the most common site of metastasis for patients diagnosed with colorectal carcinoma. Although surgical resection is the mainstay for treatment with curative intent, this option is available to a minority of patients with metastatic disease. Hepatic arterial infusion chemotherapy was developed with the intention to focus treatment on a site of difficult to control metastatic disease. In this review, we aim to present the rationale for the development of hepatic arterial infusion chemotherapy, the basic anatomic and pharmacological underpinnings of this treatment, the associated toxicities, and a brief survey of the expanding applications for this approach. Copyright © 2010 by Lippincott Williams & Wilkins. |
Keywords: | cancer chemotherapy; clinical feature; clinical trial; review; hepatitis; cisplatin; doxorubicin; fluorouracil; drug dose reduction; side effect; antineoplastic agents; liver neoplasms; gemcitabine; adjuvant therapy; cancer adjuvant therapy; chemotherapy; antineoplastic agent; animals; bleeding; dexamethasone; irinotecan; alanine aminotransferase blood level; aspartate aminotransferase blood level; colorectal carcinoma; colorectal neoplasms; alanine aminotransferase; aspartate aminotransferase; bilirubin; liver metastasis; folinic acid; infusions, intra-arterial; drug clearance; liver resection; mitomycin c; drug blood level; metastases; oxaliplatin; hematoma; floxuridine; bilirubin blood level; cholecystitis; artery thrombosis; hepatic arterial infusion; infusion pumps, implantable; technetium sulfur colloid tc 99m; anatomical variation; tumor blood flow; catheter thrombosis; hepatic arterial infusion chemotherapy; infusion pump; liver blood flow; liver perfusion; liver scintiscanning |
Journal Title: | The Cancer Journal |
Volume: | 16 |
Issue: | 2 |
ISSN: | 1528-9117 |
Publisher: | Lippincott Williams & Wilkins |
Date Published: | 2010-03-01 |
Start Page: | 142 |
End Page: | 149 |
Language: | English |
DOI: | 10.1097/PPO.0b013e3181d7ea51 |
PUBMED: | 20404611 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CAJOC" - "Source: Scopus" |