Hepatic artery infusion chemotherapy for metastatic colorectal carcinoma Journal Article
| Authors: | Koea, J. B.; Kemeny, N. |
| Article Title: | Hepatic artery infusion chemotherapy for metastatic colorectal carcinoma |
| Abstract: | Hepatic metastases are a major cause of morbidity and will affect up to 80,000 new patients annually in the United States. Up to 20% of these patients will die with metastatic disease localized to the liver. Hepatic arterial infusion (HAI) therapy has a sound anatomical and pharmacological rationale. A number of randomized clinical trials in patients with unresected metastases have demonstrated that HAI is associated with a complete response rate in 5% of patients and partial responses up to 60%. In comparison, systemic chemotherapy is associated with a partial response in 20% of cases. No investigation comparing systemic chemotherapy with HAI has demonstrated an improvement in survival following HAI, since all investigations either allowed crossover, were under-powered with respect to survival statistics, or included patients with extrahepatic disease in the HAI arm. However, a recent investigation utilizing HAI with systemic chemotherapy following hepatic resection demonstrates improved local and systemic disease control and overall survival. This approach offers new promise for the curative treatment of the patients with metastatic colorectal carcinoma. (C) 2000 Wiley-Liss, Inc. |
| Keywords: | cancer survival; controlled study; human tissue; treatment outcome; survival analysis; surgical technique; survival rate; human cell; clinical trial; neutropenia; cisplatin; doxorubicin; fluorouracil; liver neoplasms; research design; laparoscopy; colorectal cancer; disease association; controlled clinical trial; randomized controlled trial; antineoplastic combined chemotherapy protocols; drug administration schedule; dexamethasone; carmustine; colorectal neoplasms; postoperative complications; health care cost; liver metastasis; randomized controlled trials; neoplasm metastasis; infusions, intra-arterial; insulin; mitomycin c; hyperbilirubinemia; crossover procedure; floxuridine; surgical anatomy; leucovorin; cost-benefit analysis; meta analysis; hepatic artery; sclerosis; anatomical variation; dichloromethotrexate; infusion pumps; humans; prognosis; human; priority journal; article; combined antineoplastic agents; drug dose-response relationship; intra-arterial infusions; local neoplasm recurrence |
| Journal Title: | Seminars in Surgical Oncology |
| Volume: | 19 |
| Issue: | 2 |
| ISSN: | 8756-0437 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2000-09-01 |
| Start Page: | 125 |
| End Page: | 134 |
| Language: | English |
| DOI: | 10.1002/1098-2388(200009)19:2<125::aid-ssu5>3.0.co;2-e |
| PUBMED: | 11126377 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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