Surgical therapy for metastatic disease to the liver Journal Article
| Authors: | Bentrem, D. J.; DeMatteo, R. P.; Blumgart, L. H. |
| Article Title: | Surgical therapy for metastatic disease to the liver |
| Abstract: | The liver is a common site of hematogenous metastasis. In the past, patients with liver metastases were often deemed inoperable, and medical therapy conferred only minor survival benefit. However, advances in surgical techniques and chemotherapeutic agents during the past two decades have led to effective treatments for selected patients with metastases to the liver. Up to ∼80% of the liver can be resected, and partial hepatectomy is now routinely performed with a perioperative mortality rate of <5%. Surgical resection of colorectal cancer metastatic to the liver results in a 5-year survival rate of 40%. These results are expected to improve even further with multimodality approaches that include newer chemotherapy regimens. Liver metastases from other primary tumors, such as neuroendocrine carcinoma and genitourinary tumors, are also treated effectively with liver resection. The indications for surgical treatment of liver metastases are broadening as a variety of novel therapies are being developed, including hepatic artery embolization, hepatic artery infusion of chemotherapy, and radiofrequency ablation. Copyright © 2005 by Annual Reviews. All rights reserved. |
| Keywords: | cancer survival; survival rate; review; artificial embolism; multimodality cancer therapy; liver neoplasms; preoperative care; chemotherapy, adjuvant; combined modality therapy; chemotherapy; positron emission tomography; preoperative evaluation; colorectal cancer; treatment indication; metastasis; carcinoembryonic antigen; colorectal neoplasms; urogenital neoplasms; survival time; liver metastasis; feasibility studies; systematic review; surgical mortality; hepatectomy; radiofrequency ablation; partial hepatectomy; clinical examination; carcinoma, neuroendocrine; hepatic resection; colorectal metastases |
| Journal Title: | Annual Review of Medicine |
| Volume: | 56 |
| ISSN: | 0066-4219 |
| Publisher: | Annual Reviews |
| Date Published: | 2005-01-01 |
| Start Page: | 139 |
| End Page: | 156 |
| Language: | English |
| DOI: | 10.1146/annurev.med.56.082103.104630 |
| PUBMED: | 15660506 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 70" - "Export Date: 24 October 2012" - "CODEN: ARMCA" - "Source: Scopus" |
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