Management of liver metastases from colorectal cancer Journal Article
| Author: | Kemeny, N. |
| Article Title: | Management of liver metastases from colorectal cancer |
| Abstract: | The liver is a frequent site of metastatic colorectal disease. Over the past 20 years, improvements in systemic chemotherapy and surgical techniques have improved the survival of patients with hepatic metastases. For 4 decades, fluorouracil and leucovorin were the only drugs available to treat metastatic colorectal cancer, but several new drugs and a variety of novel regimens are now available. Further improvements in results have been seen with the delivery of chemotherapy via the hepatic artery. Surgical resection of liver metastases has been encouraged when possible, and recent advances in surgery such as portal vein embolization, have made liver resection a possibility for more patients. This review considers the timing and sequence of chemotherapy and surgery in this setting, as well as the roles of cryoablation, radiofrequency ablation, and radiation therapy. |
| Keywords: | cancer survival; surgical technique; clinical trial; review; bevacizumab; cisplatin; doxorubicin; erlotinib; fluorouracil; patient selection; liver neoplasms; capecitabine; adjuvant therapy; cancer radiotherapy; chemotherapy, adjuvant; neoadjuvant therapy; radiotherapy, adjuvant; methodology; antineoplastic agent; colorectal cancer; interleukin 2; metastasis; controlled clinical trial; liver toxicity; randomized controlled trial; antineoplastic combined chemotherapy protocols; drug administration schedule; combination chemotherapy; dexamethasone; continuous infusion; pathology; cetuximab; time; time factors; irinotecan; colorectal neoplasms; liver metastasis; randomized controlled trials; colorectal tumor; folinic acid; adjuvant chemotherapy; liver tumor; intraarterial drug administration; infusions, intra-arterial; colon resection; liver resection; drug administration; mitomycin; oxaliplatin; cryoablation; radiofrequency ablation; floxuridine; clinical trials; catheter ablation; cryosurgery; hepatic artery; recombinant interleukin 2; fatty liver; levamisole; uft; vein occlusion |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 20 |
| Issue: | 10 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2006-01-01 |
| Start Page: | 1161 |
| End Page: | 1176, 1179 |
| Language: | English |
| PUBMED: | 17024869 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 38" - "Export Date: 4 June 2012" - "CODEN: OCLGE" - "Source: Scopus" |
