Role of intra-arterial hepatic chemotherapy in the treatment of colorectal cancer metastases Journal Article
| Authors: | Kingham, T. P.; D'Angelica, M.; Kemeny, N. E. |
| Article Title: | Role of intra-arterial hepatic chemotherapy in the treatment of colorectal cancer metastases |
| Abstract: | Hepatic metastases are common with colorectal cancer. The primary blood supply to hepatic metastases is the hepatic artery. Regional chemotherapy utilizing the hepatic artery is one treatment option for liver metastases. The advantage of hepatic arterial chemotherapy is that high concentrations of the therapeutic drug are obtained in the liver with minimal systemic toxicity. Recently, systemic chemotherapy regimens have been added to hepatic arterial infusional chemotherapy to treat hepatic metastases. Due to the high response rates in the liver, resection rates are increasing in patients originally thought to have unresectable liver disease. Hepatic arterial chemotherapy has also been used in the adjuvant setting after resection of all liver metastases in order to minimize hepatic recurrences. The role of hepatic arterial infusional therapy in treating hepatic colorectal metastases includes treating patients with both resectable and unresectable metastases in the adjuvant, neoadjuvant, or palliative settings. © 2010 Wiley-Liss, Inc. Copyright © 2010 Wiley-Liss, Inc. |
| Keywords: | cancer chemotherapy; survival analysis; review; cancer recurrence; fluorouracil; diarrhea; antineoplastic agents; liver neoplasms; capecitabine; colorectal cancer; bone marrow suppression; mucosa inflammation; nausea; vomiting; dexamethasone; irinotecan; colorectal neoplasms; liver metastasis; digestive system ulcer; infusions, intra-arterial; liver resection; mitomycin c; oxaliplatin; floxuridine; hepatobiliary disease; hepatic artery; liver metastases; nitrosourea derivative; metastatic colorectal cancer; regional liver therapy |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 102 |
| Issue: | 8 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-12-15 |
| Start Page: | 988 |
| End Page: | 995 |
| Language: | English |
| DOI: | 10.1002/jso.21753 |
| PUBMED: | 21166003 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: JSONA" - "Source: Scopus" |
