Non-surgical treatment for liver metastases Journal Article
| Authors: | Kemeny, N. E.; Atiq, O. T. |
| Article Title: | Non-surgical treatment for liver metastases |
| Abstract: | The liver is a common site for developing metastatic disease. Although any malignancy can spread to the liver, the direct passage of blood from the gastrointestinal tract to the liver via the portal circulation results in a high rate of liver metastasis from gastrointestinal tract tumours. Various radiographical tests including computed tomography and magnetic resonance imaging can detect the majority of liver metastases. Surgical resection if feasible is the treatment of choice since it produces a 5-year survival rate of about 30%. However, the majority of the patients relapse after hepatic resection, 50% relapsing in the liver. Systemic chemotherapy produces response rates of 15-30% with a median survival of 10-12 months. It is estimated that 30,000 patients each year in the USA are candidates for regional hepatic therapy. Hepatic arterial chemotherapy, hepatic artery embolization, chemoembolization, cryosurgery, ethanol injection of the tumour and radiation therapy are being investigated as potential treatment options for such patients. |
| Keywords: | cancer chemotherapy; cancer survival; treatment outcome; unclassified drug; review; cisplatin; doxorubicin; fluorouracil; iodinated poppyseed oil; artificial embolism; diarrhea; liver neoplasms; cancer adjuvant therapy; nuclear magnetic resonance imaging; antineoplastic agent; computer assisted tomography; liver toxicity; bone marrow suppression; nausea; vomiting; antineoplastic combined chemotherapy protocols; dexamethasone; patient monitoring; carmustine; irinotecan; bilirubin; liver metastasis; folinic acid; alcohol; gene therapy; liver resection; mitomycin c; liver enzyme; floxuridine; hepatobiliary disease; ethylnitrosourea; cryosurgery; hepatic artery; gelfoam; liver metastases; chemoembolization, therapeutic; gastritis; raltitrexed; peptic ulcer; injections, intra-arterial; primary sclerosing cholangitis; biliary cirrhosis; humans; human; oxalaplatin; duodenitis |
| Journal Title: | Baillière's Best Practice and Research in Clinical Gastroenterology |
| Volume: | 13 |
| Issue: | 4 |
| ISSN: | 1521-6918 |
| Publisher: | Harcourt Publishers Ltd |
| Date Published: | 1999-12-01 |
| Start Page: | 593 |
| End Page: | 610 |
| Language: | English |
| DOI: | 10.1053/bega.1999.0050 |
| PUBMED: | 10654922 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
