| Abstract: |
Locoregional therapies play a significant role in the management of patients with colorectal liver metastases due to the high rate of unresectable disease in these patients. Intra-arterial therapies defines a category of locoregional liver therapies that take advantage of the arterial-predominant perfusion of colorectal liver metastases to treat lesions, with the goal of converting patients to resectable disease or palliating disease. Intra-arterial therapies include embolization, chemoembolization, radioembolization, and hepatic artery infusion chemotherapy. Here we review the techniques, indications, and data supporting each of these approaches. In brief, embolic therapies have little if any significant data supporting their effectiveness in colorectal liver metastases but hepatic artery infusion chemotherapy has demonstrated treatment response in several different clinical scenarios and is increasingly being implemented and studied. © 2022 Elsevier Inc. All rights reserved. |
