Lobular carcinoma, not only a classic Journal Article
| Authors: | Brogi, E.; Murray, M. P.; Corben, A. D. |
| Article Title: | Lobular carcinoma, not only a classic |
| Abstract: | Lobular carcinoma in situ (LCIS) and atypical lobular hyperplasia are rare lesions, found incidentally in breast biopsies. They have been regarded traditionally as high-risk lesions, but recent genetic evidence and follow-up data indicates that they also constitute nonobligate precursors of invasive carcinoma. In addition to 16q deletion, a genetic alteration common across the spectrum of low-grade mammary epithelial neoplasia, lobular lesions consistently demonstrate deletion or functional inactivation of the CDH1/E-cadherin gene, with consequent loss of membranous immunoreactivity for the same antigen. The use of E-cadherin in the evaluation of solid mammary carcinoma in situ with ambiguous morphology has identified variants of LCIS characterized by massive acinar expansion and necrosis with calcifications, and/or marked nuclear pleomorphism or signet ring cell formation. In contrast to classic LCIS, these rare lesions are detected mammographically and often occur in association with invasive carcinoma. Genetic analysis of these tumors has confirmed lobular lineage and demonstrated more extensive chromosomal alterations than in classic LCIS. A pleomorphic variant of invasive lobular carcinoma has also been described. Here, we summarize our evolving knowledge of in situ and invasive lobular neoplasia and highlight the implications for patient management. © 2010 Wiley Periodicals, Inc. |
| Keywords: | gene mutation; review; follow up; genetic analysis; breast cancer; genetic variability; breast neoplasms; uvomorulin; high risk patient; mammography; breast carcinoma; invasive carcinoma; chromosome aberrations; chromosome deletion; cadherins; intraductal carcinoma; acinar cell; breast biopsy; chromosome 6q; chromosome 16q; lobular carcinoma in situ; carcinoma, lobular; chromosome 17p; chromosome 22q; atypical lobular hyperplasia; core biopsy; florid lcis; lcis with comedonecrosis; pleomorphic lobular carcinoma; chromosome 16p; invasive pleomorphic lobular carcinoma |
| Journal Title: | Breast Journal |
| Volume: | 16 |
| Issue: | Suppl. |
| ISSN: | 1075-122X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-09-01 |
| Start Page: | S10 |
| End Page: | S14 |
| Language: | English |
| DOI: | 10.1111/j.1524-4741.2010.00994.x |
| PUBMED: | 21050299 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: BRJOF" - "Source: Scopus" |
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