Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas Review

  


Authors: Calle, C.; Kuba, M. G.; Brogi, E.
Review Title: Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas
Abstract: The designation of noninvasive lobular neoplasia applies to atypical epithelial proliferations composed of noncohesive cells secondary to loss or functional alteration of E-cadherin-mediated cell adhesion. The morphologic spectrum of noninvasive lobular neoplasia encompasses atypical lobular hyperplasia (ALH) and classic lobular carcinoma in situ (classic LCIS) and two LCIS variants, namely florid LCIS (F-LCIS) and pleomorphic LCIS (P-LCIS), as defined in the World Health Organization (WHO) Classification of Tumors of the Breast 5th ed. Herein, we review the morphologic, immunohistochemical, and molecular features of noninvasive lobular neoplasia, with special emphasis on F-LCIS and P-LCIS. We also review imaging features, management at core needle biopsy, upgrade rates at surgical excision, and clinical management dilemmas. © 2020 Wiley Periodicals, Inc.
Keywords: immunohistochemistry; cancer surgery; clinical feature; cancer staging; uvomorulin; breast tumor; morphological trait; lobular carcinoma in situ; pleomorphic lobular carcinoma in situ; atypical lobular hyperplasia; upgrade; large core needle biopsy; human; article; atypical lobular hyperplasia (alh); florid lobular carcinoma in situ (flcis); lobular carcinoma in situ (lcis); pleomorphic lobular carcinoma in situ (plcis); florid lobular carcinoma in situ; non invasive lobular breast neoplasia
Journal Title: Breast Journal
Volume: 26
Issue: 6
ISSN: 1075-122X
Publisher: Wiley Blackwell  
Date Published: 2020-06-01
Start Page: 1148
End Page: 1155
Language: English
DOI: 10.1111/tbj.13857
PUBMED: 32500575
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085994949&doi=10.1111%2ftbj.13857&partnerID=40&md5=9406c8d2e7b795701480729c2d76dfe4
Notes: Article -- Export Date: 3 August 2020 -- Source: Scopus
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MSK Authors
  1. Edi Brogi
    515 Brogi
  2. Maria Gabriela Kuba
    29 Kuba
  3. Catarina Calle
    4 Calle
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