The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS Review
| Author: | Brogi, E. |
| Review Title: | The morphologic spectrum of lobular carcinoma in situ (LCIS) observations on clinical significance, management implications and diagnostic pitfalls of classic, florid and pleomorphic LCIS |
| Abstract: | Lobular carcinoma in situ (LCIS) is a non-invasive proliferation of atypical dyscohesive epithelial cells characterized by loss or functional alteration of E-cadherin-mediated cell adhesion. The morphologic spectrum of LCIS encompasses classic (C-LCIS), florid (F-LCIS) and pleomorphic LCIS (P-LCIS), as recently defined by the World Health Organization (WHO) Expert Consensus Group. Atypical lobular hyperplasia (ALH) is also part of this spectrum. This article highlights the morphologic and immunohistochemical features of the three forms of LCIS and summarizes their management implications and prognosis, with emphasis on F-LCIS and P-LCIS. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
| Keywords: | pathology; breast neoplasms; risk; breast tumor; carcinoma in situ; hyperplasia; e-cadherin; carcinoma, lobular; lobular carcinoma; clinical relevance; upgrade; humans; human; female; breast carcinoma in situ; florid lobular carcinoma in situ (f-lcis); pleomorphic lobular carcinoma in situ (p-lcis) |
| Journal Title: | Virchows Archiv |
| Volume: | 481 |
| Issue: | 6 |
| ISSN: | 0945-6317 |
| Publisher: | Springer |
| Date Published: | 2022-12-01 |
| Start Page: | 823 |
| End Page: | 837 |
| Language: | English |
| DOI: | 10.1007/s00428-022-03299-3 |
| PUBMED: | 35567633 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 January 2023 -- Source: Scopus |
