Aberrant E-cadherin staining patterns in invasive mammary carcinoma Journal Article
| Authors: | Harigopal, M.; Shin, S. J.; Murray, M. P.; Tickoo, S. K.; Brogi, E.; Rosen, P. P. |
| Article Title: | Aberrant E-cadherin staining patterns in invasive mammary carcinoma |
| Abstract: | Background: E-cadherin, a cell surface protein involved in cell adhesion, is present in normal breast epithelium, benign breast lesions, and in breast carcinoma. Alterations in the gene CDH1 on chromosome 16q22 are associated with changes in E-cadherin protein expression and function. Inactivation of E-cadherin in lobular carcinomas and certain diffuse gastric carcinomas may play a role in the dispersed, discohesive "single cell" growth patterns seen in these tumors. The molecular "signature" of mammary lobular carcinomas is the loss of E-cadherin protein expression as evidenced by immunohistochemistry, whereas ductal carcinomas are typically E-cadherin positive. Patients and Methods: We report on E-cadherin immunostaining patterns in five cases of invasive mammary carcinoma. Results: These were five exceptional instances in which the E-cadherin immunophenotype did not correspond to the apparent histologic classification of the lesion. These cases which are exceedingly rare in our experience are the subject of this report. Conclusions: Findings such as those illustrated in this study occur in virtually all biologic phenomena and they do not invalidate the very high degree of correlation between the expression of E-cadherin and the classification of breast carcinomas as ductal or lobular type on the basis of conventional histologic criteria. © 2005 Harigopal et al., licensee BioMed Central Ltd. |
| Keywords: | immunohistochemistry; adult; clinical article; controlled study; human tissue; protein expression; human cell; histopathology; microscopy; validation process; protein function; tumor volume; uvomorulin; cancer invasion; correlation analysis; breast carcinoma; immunophenotyping; cancer classification; breast biopsy; cell surface protein |
| Journal Title: | World Journal of Surgical Oncology |
| Volume: | 3 |
| ISSN: | 1477-7819 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2005-01-01 |
| Start Page: | 73 |
| Language: | English |
| DOI: | 10.1186/1477-7819-3-73 |
| PROVIDER: | scopus |
| PMCID: | PMC1308872 |
| PUBMED: | 16287501 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 24 October 2012" - "Source: Scopus" |
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