Cellular responses to extracellular guidance cues Journal Article
| Authors: | Berzat, A.; Hall, A. |
| Article Title: | Cellular responses to extracellular guidance cues |
| Abstract: | Extracellular guidance cues have a key role in orchestrating cell behaviour. They can take many forms, including soluble and cell-bound ligands (proteins, lipids, peptides or small molecules) and insoluble matrix substrates, but to act as guidance cues, they must be presented to the cell in a spatially restricted manner. Cells that recognize such cues respond by activating intracellular signal transduction pathways in a spatially restricted manner and convert the extracellular information into intracellular polarity. Although extracellular cues influence a broad range of cell polarity decisions, such as mitotic spindle orientation during asymmetric cell division, or the establishment of apicalĝ€"basal polarity in epithelia, this review will focus specifically on guidance cues that promote cell migration (chemotaxis), or localized cell shape changes (chemotropism). © 2010 European Molecular Biology Organization. |
| Keywords: | signal transduction; review; nonhuman; animals; cell division; cell function; extracellular matrix; chemotaxis; nerve fiber; cell migration; cell polarity; mitosis spindle; yeast; cell shape; nerve cell; polarity; chemotropism; guidance cue |
| Journal Title: | EMBO Journal |
| Volume: | 29 |
| Issue: | 16 |
| ISSN: | 0261-4189 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-08-18 |
| Start Page: | 2734 |
| End Page: | 2745 |
| Language: | English |
| DOI: | 10.1038/emboj.2010.170 |
| PUBMED: | 20717143 |
| PROVIDER: | scopus |
| PMCID: | PMC2924648 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: EMJOD" - "Source: Scopus" |
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