Cellular responses to extracellular guidance cues Journal Article


Authors: Berzat, A.; Hall, A.
Article Title: Cellular responses to extracellular guidance cues
Abstract: Extracellular guidance cues have a key role in orchestrating cell behaviour. They can take many forms, including soluble and cell-bound ligands (proteins, lipids, peptides or small molecules) and insoluble matrix substrates, but to act as guidance cues, they must be presented to the cell in a spatially restricted manner. Cells that recognize such cues respond by activating intracellular signal transduction pathways in a spatially restricted manner and convert the extracellular information into intracellular polarity. Although extracellular cues influence a broad range of cell polarity decisions, such as mitotic spindle orientation during asymmetric cell division, or the establishment of apicalĝ€"basal polarity in epithelia, this review will focus specifically on guidance cues that promote cell migration (chemotaxis), or localized cell shape changes (chemotropism). © 2010 European Molecular Biology Organization.
Keywords: signal transduction; review; nonhuman; animals; cell division; cell function; extracellular matrix; chemotaxis; nerve fiber; cell migration; cell polarity; mitosis spindle; yeast; cell shape; nerve cell; polarity; chemotropism; guidance cue
Journal Title: EMBO Journal
Volume: 29
Issue: 16
ISSN: 0261-4189
Publisher: Wiley Blackwell  
Date Published: 2010-08-18
Start Page: 2734
End Page: 2745
Language: English
DOI: 10.1038/emboj.2010.170
PUBMED: 20717143
PROVIDER: scopus
PMCID: PMC2924648
DOI/URL:
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: EMJOD" - "Source: Scopus"
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  1. Alan Hall
    41 Hall
  2. Anastacia Berzat
    1 Berzat