Factors associated with attrition from a randomized controlled trial of meaning-centered group psychotherapy for patients with advanced cancer Journal Article


Authors: Applebaum, A. J.; Lichtenthal, W. G.; Pessin, H. A.; Radomski, J. N.; Simay Gökbayrak, N.; Katz, A. M.; Rosenfeld, B.; Breitbart, W.
Article Title: Factors associated with attrition from a randomized controlled trial of meaning-centered group psychotherapy for patients with advanced cancer
Abstract: Objective The generalizability of palliative care intervention research is often limited by high rates of study attrition. This study examined factors associated with attrition from a randomized controlled trial comparing meaning-centered group psychotherapy (MCGP), an intervention designed to help advanced cancer patients sustain or enhance their sense of meaning to the supportive group psychotherapy (SGP), a standardized support group. Methods Patients with advanced solid tumor cancers (n = 153) were randomized to eight sessions of either the MCGP or SGP. They completed assessments of psychosocial, spiritual, and physical well-being pretreatment, midtreatment, and 2 months post-treatment. Attrition was assessed in terms of the percent of participants who failed to complete these assessments, and demographic, psychiatric, medical, and study-related correlates of attrition were examined for the participants in each of these categories. Results The rates of attrition at these time points were 28.1%, 17.7%, and 11.1%, respectively; 43.1% of the participants (66 of 153) completed the entire study. The most common reason for dropout was patients feeling too ill. Attrition rates did not vary significantly between study arms. The participants who dropped out pretreatment reported less financial concerns than post-treatment dropouts, and the participants who dropped out of the study midtreatment had poorer physical health than treatment completers. There were no other significant associations between attrition and any demographic, medical, psychiatric, or study-related variables. Conclusions These findings highlight the challenge of maintaining advanced cancer patients in longitudinal research and suggest the need to consider alternative approaches (e.g., telemedicine) for patients who might benefit from group interventions but are too ill to travel. Copyright © 2011 John Wiley & Sons, Ltd.
Keywords: palliative care; meaning; psychotherapy; attrition
Journal Title: Psycho-Oncology
Volume: 21
Issue: 11
ISSN: 1057-9249
Publisher: John Wiley & Sons  
Date Published: 2012-01-01
Start Page: 1195
End Page: 1204
Language: English
DOI: 10.1002/pon.2013
PROVIDER: scopus
PUBMED: 21751295
PMCID: PMC3827859
DOI/URL:
Notes: --- - "Export Date: 3 December 2012" - "CODEN: POJCE" - "Source: Scopus"
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  1. William S Breitbart
    505 Breitbart
  2. Allison Joyce Applebaum
    191 Applebaum
  3. Hayley Ann Pessin
    88 Pessin