Structure and activities of the eukaryotic RNA exosome Journal Article


Authors: Wasmuth, E. V.; Lima, C. D.
Article Title: Structure and activities of the eukaryotic RNA exosome
Abstract: The composition of the multisubunit eukaryotic RNA exosome was described more than a decade ago, and structural studies conducted since that time have contributed to our mechanistic understanding of factors that are required for 3'-to-5' RNA processing and decay. This chapter describes the organization of the eukaryotic RNA exosome with a focus on presenting results related to the noncatalytic nine-subunit exosome core as well as the hydrolytic exo- and endoribonuclease Rrp44 (Dis3) and the exoribonuclease Rrp6. This is achieved in large part by describing crystal structures of Rrp44, Rrp6, and the nine-subunit exosome core with an emphasis on how these molecules interact to endow the RNA exosome with its catalytic activities. © 2012 Elsevier Inc.
Keywords: rna processing; rna binding; rna degradation; structure; exosome; exoribonuclease; 3'-to-5' rna decay; cold-shock domain; endoribonuclease; hydrolytic; kh domain; multisubunit; ph domain; phosphorolytic; pin domain; rnase; s1 domain
Journal Title: Enzymes
Volume: 31
ISSN: 1874-6047
Publisher: Elsevier Inc.  
Date Published: 2012-01-01
Start Page: 53
End Page: 75
Language: English
DOI: 10.1016/b978-0-12-404740-2.00003-3
PROVIDER: scopus
PMCID: PMC5336833
PUBMED: 27166440
DOI/URL:
Notes: --- - "Export Date: 2 November 2012" - "Source: Scopus"
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  1. Christopher D Lima
    95 Lima
  2. Elizabeth Wasmuth
    10 Wasmuth