Structure and activities of the eukaryotic RNA exosome Journal Article
| Authors: | Wasmuth, E. V.; Lima, C. D. |
| Article Title: | Structure and activities of the eukaryotic RNA exosome |
| Abstract: | The composition of the multisubunit eukaryotic RNA exosome was described more than a decade ago, and structural studies conducted since that time have contributed to our mechanistic understanding of factors that are required for 3'-to-5' RNA processing and decay. This chapter describes the organization of the eukaryotic RNA exosome with a focus on presenting results related to the noncatalytic nine-subunit exosome core as well as the hydrolytic exo- and endoribonuclease Rrp44 (Dis3) and the exoribonuclease Rrp6. This is achieved in large part by describing crystal structures of Rrp44, Rrp6, and the nine-subunit exosome core with an emphasis on how these molecules interact to endow the RNA exosome with its catalytic activities. © 2012 Elsevier Inc. |
| Keywords: | rna processing; rna binding; rna degradation; structure; exosome; exoribonuclease; 3'-to-5' rna decay; cold-shock domain; endoribonuclease; hydrolytic; kh domain; multisubunit; ph domain; phosphorolytic; pin domain; rnase; s1 domain |
| Journal Title: | Enzymes |
| Volume: | 31 |
| ISSN: | 1874-6047 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-01-01 |
| Start Page: | 53 |
| End Page: | 75 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-404740-2.00003-3 |
| PROVIDER: | scopus |
| PMCID: | PMC5336833 |
| PUBMED: | 27166440 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "Source: Scopus" |
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