The eukaryotic RNA exosome Journal Article


Authors: Januszyk, K.; Lima, C. D.
Article Title: The eukaryotic RNA exosome
Abstract: The eukaryotic RNA exosome is an essential multi-subunit ribonuclease complex that contributes to the degradation or processing of nearly every class of RNA in both the nucleus and cytoplasm. Its nine-subunit core shares structural similarity to phosphorolytic exoribonucleases such as bacterial PNPase. PNPase and the RNA exosome core feature a central channel that can accommodate single stranded RNA although unlike PNPase, the RNA exosome core is devoid of ribonuclease activity. Instead, the core associates with Rrp44, an endoribonuclease and processive 3'. →. 5' exoribonuclease, and Rrp6, a distributive 3'. →. 5' exoribonuclease. Recent biochemical and structural studies suggest that the exosome core is essential because it coordinates Rrp44 and Rrp6 recruitment, RNA can pass through the central channel, and the association with the core modulates Rrp44 and Rrp6 activities. © 2014 Elsevier Ltd.
Journal Title: Current Opinion in Structural Biology
Volume: 24
ISSN: 0959-440X
Publisher: Elsevier Inc.  
Date Published: 2014-02-01
Start Page: 132
End Page: 140
Language: English
DOI: 10.1016/j.sbi.2014.01.011
PROVIDER: scopus
PMCID: PMC3985421
PUBMED: 24525139
DOI/URL:
Notes: Export Date: 3 March 2014 -- CODEN: COSBE -- Source: Scopus
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  1. Christopher D Lima
    95 Lima