Recurrent non-small cell lung cancer: Evaluation of CT-guided radiofrequency ablation as salvage therapy Journal Article
| Authors: | Schoellnast, H.; Deodhar, A.; Hsu, M.; Moskowitz, C.; Nehmeh, S. A.; Thornton, R. H.; Sofocleous, C. T.; Alago, W.; Downey, R. J.; Azzoli, C. G.; Rosenzweig, K. E.; Solomon, S. B. |
| Article Title: | Recurrent non-small cell lung cancer: Evaluation of CT-guided radiofrequency ablation as salvage therapy |
| Abstract: | Background: Radiofrequency ablation (RFA) is a potential application as a salvage tool after failure of surgery, chemotherapy, or radiotherapy of non-small cell lung cancer (NSCLC). Although several studies have evaluated the use of RFA in primary NSCLC, there is little literature on its potential application as a salvage tool. Purpose: To evaluate CT-guided RFA employed as a salvage therapy for pulmonary recurrences of NSCLC after prior treatment with chemotherapy, radiation therapy, and/or surgery. Material and Methods: A retrospective computer database search yielded 33 patients with biopsy proven primary NSCLC who underwent CT-guided RFA of 39 recurrent tumors following surgery, chemotherapy, and/or radiotherapy. Follow-up imaging was performed with CT and PET-CT. The endpoints of interest were progression-free survival (PFS) and time to local progression (TTLP). PFS and TTLP were compared by lesion size (<3 cm, ≥3 cm). Results: The median PFS was 8 months. For patients with a tumor size <3 cm median PFS was 11 months, whereas the median PFS of patients with a tumor size ≥3 cm was 5 months. The difference did not reach statistical significance (P = 0.09). The median TTLP of all tumors was 14 months. TTLP of ablated tumors <3 cm in size was 24 months, compared to 8 months for ablated tumors ≥3 cm in size. The difference did not reach statistical significance (P = 0.07). Conclusion: RFA of recurrent NSCLC may be a valuable salvage tool to achieve local tumor control, especially in tumors measuring <3 cm in size. |
| Keywords: | survival; treatment outcome; aged; aged, 80 and over; disease-free survival; middle aged; survival rate; retrospective studies; disease course; mortality; salvage therapy; disease free survival; chemotherapy; follow up; follow-up studies; progression free survival; computer assisted tomography; neoplasm recurrence, local; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy; tomography, x-ray computed; retrospective study; lung tumor; length of stay; statistical significance; tumors; disease progression; tumor recurrence; surgery; radiography; lung carcinoma; kaplan meier method; medical computing; biological organs; diseases; catheter ablation; surgical equipment; surgery, computer-assisted; tumor size; non small cell lung cancer; percutaneous radiofrequency ablation; kaplan-meier estimate; ablation; potential applications; local tumor control; computer assisted surgery; radio-frequency ablation; local tumor progression; tumor progressions; lesion size; computer database; non-small-cell lung carcinoma; search engines; recurrent tumors |
| Journal Title: | Acta Radiologica |
| Volume: | 53 |
| Issue: | 8 |
| ISSN: | 0284-1851 |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 2012-10-01 |
| Start Page: | 893 |
| End Page: | 899 |
| Language: | English |
| DOI: | 10.1258/ar.2012.110333 |
| PROVIDER: | scopus |
| PUBMED: | 22961644 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 November 2012" - "CODEN: ACRAE" - "Source: Scopus" |
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