Micropapillary and/or solid histologic subtype based on pre-treatment biopsy predicts local recurrence after thermal ablation of lung adenocarcinoma Journal Article
| Authors: | Gao, S.; Stein, S.; Petre, E. N.; Shady, W.; Durack, J. C.; Ridge, C.; Adusumilli, P.; Rekhtman, N.; Solomon, S. B.; Ziv, E. |
| Article Title: | Micropapillary and/or solid histologic subtype based on pre-treatment biopsy predicts local recurrence after thermal ablation of lung adenocarcinoma |
| Abstract: | Background: To investigate whether histologic subtyping from biopsies can predict local recurrence after thermal ablation for lung adenocarcinoma. Methods: Patients treated with CT-guided thermal ablation for lung adenocarcinoma that had pre-ablation needle biopsy with analysis of histologic components were identified. Age, gender, smoking status, treatment indication (primary stage 1 tumor versus salvage), histologic subtype, ground-glass radiographic appearance, tumor size, ablation modality, and ablation margin were evaluated in relation to time to local recurrence (TTLR). Cumulative incidence of recurrence (CIR) was calculated using competing risks analysis and compared across groups using Fine and Grey method with clustering. Multivariate analysis was conducted with stepwise regression. Results: There were 53 patients with 57 tumors diagnosed as adenocarcinoma on pre-ablation biopsy and with histologic subtype analysis. Of these, 19% (11) had micropapillary components, 14% (8) had solid components, and 26% (15) had micropapillary and/or solid components. In the univariate analysis, solid (subdistribution hazard ratio [SHR] = 4.04, p = 0.0051, 95% confidence interval [CI] = 1.52–10.7), micropapillary (SHR = 3.36, p = 0.01, CI = 1.33–8.47), and micropapillary and/or solid components (SHR = 5.85, p = 0.00038, CI = 2.21–15.5) were significantly correlated with shorter TTLR. On multivariate analysis, the presence of micropapillary and/or solid component (SHR = 11.4, p = 0.00021, CI: 3.14–41.3) was the only independent predictor of TTLR. The 1-, 2-, and 3-year CIR in patients with micropapillary and/or solid components was 33, 49, and 66% compared to 5, 14, and 18% in patients with no micropapillary or solid components on biopsy specimens. Conclusion: Micropapillary and/or solid histologic components identified in pre-ablation biopsy are associated with shorter TTLR after thermal ablation of lung adenocarcinoma. © 2017, Springer Science+Business Media, LLC and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). |
| Keywords: | adult; controlled study; human tissue; aged; major clinical study; histopathology; cancer recurrence; salvage therapy; treatment duration; cancer staging; recurrence risk; cancer diagnosis; treatment indication; computer assisted tomography; tumor volume; tumor biopsy; prediction; age; lung adenocarcinoma; needle biopsy; smoking habit; cancer classification; gender; local recurrence; tumor ablation; thermal ablation; histologic subtype; human; male; female; priority journal; article; lung ablation; micropapillary and solid |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 41 |
| Issue: | 2 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2018-02-01 |
| Start Page: | 253 |
| End Page: | 259 |
| Language: | English |
| DOI: | 10.1007/s00270-017-1760-8 |
| PROVIDER: | scopus |
| PMCID: | PMC5760368 |
| PUBMED: | 28770314 |
| DOI/URL: | |
| Notes: | Erratum issued, see DOI: 10.1007/s00270-017-1767-1 -- Article -- Export Date: 1 March 2018 -- Source: Scopus |
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