Validation of a nomogram for predicting disease-specific survival after an RO resection for gastric carcinoma Journal Article
| Authors: | Peeters, K. C. M. J.; Kattan, M. W.; Hartgrink, H. H.; Kranenbarg, E. K.; Karpeh, M. S.; Brennan, M. F.; Van de Velde, C. J. H. |
| Article Title: | Validation of a nomogram for predicting disease-specific survival after an RO resection for gastric carcinoma |
| Abstract: | BACKGROUND. A statistical model for predicting disease-specific survival in patients with gastric carcinoma, based on a single U.S. institution experience, was tested for validity in a sample of patients treated at different institutions. METHODS. The authors analysed 459 patients from the Dutch Gastric Cancer trial that compared limited (D1) with extended (D2) lymph node dissection. The discrimination ability of the nomogram with respect to 5 and 9-year disease-specific survival probabilities was superior to that of the American Joint Committee on Cancer (AJCC) staging system. RESULTS. There was considerable heterogeneity of risk within many of the AJCC stages. Calibration plots suggested that predicted probabilities from the nomogram corresponded closely to actual disease-specific survival. The gastric carcinoma nomogram performed well when applied to patients treated in a large number of institutions. CONCLUSIONS. The nomogram provided predictions that discriminated better than the AJCC staging system, regardless of the extent of lymph node dissection. Patient counseling and adjuvant therapy decision-making should benefit from use of the nomogram. ©2005 American Cancer Society. |
| Keywords: | adult; cancer survival; aged; aged, 80 and over; disease-free survival; middle aged; cancer surgery; major clinical study; cancer adjuvant therapy; cancer staging; lymph node dissection; diagnostic accuracy; lymph node excision; prediction; risk assessment; cell heterogeneity; netherlands; diagnostic value; nomograms; forecasting; surgery; decision making; statistical model; stomach carcinoma; stomach neoplasms; nomogram; patient counseling; gastric carcinoma; american joint committee on cancer stage of disease |
| Journal Title: | Cancer |
| Volume: | 103 |
| Issue: | 4 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2005-02-15 |
| Start Page: | 702 |
| End Page: | 707 |
| Language: | English |
| DOI: | 10.1002/cncr.20783 |
| PUBMED: | 15641033 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 37" - "Export Date: 24 October 2012" - "CODEN: CANCA" - "Source: Scopus" |
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