Validation of a postresection pancreatic adenocarcinoma nomogram for disease-specific survival Journal Article
| Authors: | Ferrone, C. R.; Kattan, M. W.; Tomlinson, J. S.; Thayer, S. P.; Brennan, M. F.; Warshaw, A. L. |
| Article Title: | Validation of a postresection pancreatic adenocarcinoma nomogram for disease-specific survival |
| Abstract: | Purpose: Nomograms are statistically based tools that provide the overall probability of a specific outcome. They have shown better individual discrimination than the current TNM staging system in numerous patient tumor models. The pancreatic nomogram combines individual clinicopathologic and operative data to predict disease-specific survival at 1, 2, and 3 years from initial resection. A single US institution database was used to test the validity of the pancreatic adenocarcinoma nomogram established at Memorial Sloan-Kettering Cancer Center. Patients and Methods: The nomogram was created from a prospective pancreatic adenocarcinoma database that included 555 consecutive patients between October 1983 and April 2000. The nomogram was validated by an external patient cohort from a retrospective pancreatic adenocarcinoma database at Massachusetts General Hospital that included 424 consecutive patients between January 1985 and December 2003. Results: Of the 424 patients, 375 had all variables documented. At last follow-up, 99 patients were alive, with a median follow-up time of 27 months (range, 2 to 151 months). The 1-, 2-, and 3-year disease-specific survival rates were 68% (95% CI, 63% to 72%), 39% (95% CI, 34% to 44%), and 27% (95% CI, 23% to 32%), respectively. The nomogram concordance index was 0.62 compared with 0.59 with the American Joint Committee on Cancer (AJCC) stage (P = .004). This suggests that the nomogram discriminates disease-specific survival better than the AJCC staging system. Conclusion: The pancreatic cancer nomogram provides more accurate survival predictions than the AJCC staging system when applied to an external patient cohort. The nomogram may aid in more accurately counseling patients and in better stratifying patients for clinical trials and molecular tumor analysis. © 2005 by American Society of Clinical Oncology. |
| Keywords: | adult; cancer survival; controlled study; aged; disease-free survival; cancer surgery; survival rate; major clinical study; mortality; united states; cancer patient; disease free survival; pancreatic neoplasms; cancer staging; follow up; neoplasm staging; adenocarcinoma; cohort studies; cohort analysis; pathology; validation study; data base; nomograms; models, statistical; pancreas tumor; prediction and forecasting; predictive value of tests; pancreas adenocarcinoma; statistical model; nomogram |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 23 |
| Issue: | 30 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2005-10-20 |
| Start Page: | 7529 |
| End Page: | 7535 |
| Language: | English |
| DOI: | 10.1200/jco.2005.01.8101 |
| PUBMED: | 16234519 |
| PROVIDER: | scopus |
| PMCID: | PMC3903268 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 34" - "Export Date: 24 October 2012" - "CODEN: JCOND" - "Source: Scopus" |
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