Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma Journal Article
| Authors: | Kattan, M. W.; Karpeh, M. S.; Mazumdar, M.; Brennan, M. F. |
| Article Title: | Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma |
| Abstract: | Purpose: Few published studies have addressed individual patient risk after RO resection for gastric cancer. We developed and internally validated a nomogram that combines these factors to predict the probability of 5-year gastric cancer-specific survival on the basis of 1,039 patients treated at a single institution. Methods: Nomogram predictor variables included age, sex, primary site (distal one-third, middle one-third, gastroesophageal junction, and proximal one-third), Lauren histotype (diffuse, intestinal, mixed), number of positive lymph nodes resected, number of negative lymph nodes resected, and depth of invasion. Death as a result of gastric cancer was the predicted end point. The concordance index was used as an accuracy measure, with bootstrapping to correct for optimistic bias. Calibration plots were constructed. Results: Gastric cancer-specific survival at 5 years was 50%. A nomogram was constructed on the basis of a Cox regression model. The bootstrap-corrected concordance index was 0.80. When compared with the predictive ability of American Joint Committee on Cancer stage, the nomogram discrimination was superior (P < .001). Nomogram calibration appeared to be excellent. Conclusion: A nomogram was developed to predict 5-year disease-specific survival after R0 resection for gastric cancer. This tool should be useful for patient counseling, follow-up scheduling, and clinical trial eligibility determination. © 2003 by American Society of Clinical Oncology. |
| Keywords: | adult; cancer survival; controlled study; aged; disease-free survival; middle aged; cancer surgery; retrospective studies; major clinical study; postoperative period; cancer risk; disease free survival; cancer staging; follow up; lymph node metastasis; lymphatic metastasis; neoplasm staging; risk factors; age factors; pathology; retrospective study; risk factor; age; cancer invasion; death; models, statistical; forecasting; neoplasm invasiveness; statistical model; stomach carcinoma; stomach neoplasms; nomogram; stomach tumor; stomach surgery; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 21 |
| Issue: | 19 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2003-10-01 |
| Start Page: | 3647 |
| End Page: | 3650 |
| Language: | English |
| DOI: | 10.1200/jco.2003.01.240 |
| PUBMED: | 14512396 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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