Relationship of Nm23 expression to proliferation and prognosis in malignant melanomas of the oral cavity Journal Article
| Authors: | Korabiowska, M.; Hönig, J. F.; Jawien, J.; Knapik, J.; Stachura, J.; Cordon-Cardo, C.; Fischer, G. |
| Article Title: | Relationship of Nm23 expression to proliferation and prognosis in malignant melanomas of the oral cavity |
| Abstract: | Twenty-nine cases of oral melanomas were investigated for nm23 and Ki67 antigen expression, as well as for the fraction of tumour cells in S-phase, using immunohistochemical techniques and DNA cytophotometry. Nm23 expression was significantly reduced and Ki67 antigen expression increased in primary tumours with either lymph node or organ metastases in comparison to tumours without metastases. The percentages of Ki67 immunoreactive tumour cells and cells in S-phase correlated positively with each other and negatively with the percentage of nm23-expressing cells. These data argue against a significant growth stimulatory function of the nm23H1 gene product nucleoside diphopshate kinase in the progression of oral melanomas. The functional relevance of nm23 in relation to increased proliferation and metastatic spread is discussed. |
| Keywords: | immunohistochemistry; adult; clinical article; controlled study; human tissue; aged; aged, 80 and over; middle aged; cancer growth; pathophysiology; lymph node metastasis; lymphatic metastasis; protein function; ki 67 antigen; antigen expression; cell proliferation; ki-67 antigen; cell cycle s phase; melanoma; tumor markers, biological; immunoreactivity; gene expression regulation, neoplastic; correlation analysis; dna; neoplasm metastasis; melanoma cell; mouth neoplasms; mouth cancer; s phase; nm23; nucleoside diphosphate kinase; nucleoside-diphosphate kinase; s-phase; genes, neoplasm; oral melanoma; cas200; ki67 antigen; cytophotometry |
| Journal Title: | In Vivo |
| Volume: | 19 |
| Issue: | 6 |
| ISSN: | 0258-851X |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2005-11-01 |
| Start Page: | 1093 |
| End Page: | 1096 |
| Language: | English |
| PUBMED: | 16277028 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 24 October 2012" - "CODEN: IVIVE" - "Source: Scopus" |
