Modern management of respiratory failure due to pulmonary mycoses following allogeneic hematopoietic stem-cell transplantation Journal Article


Authors: Koldehoff, M.; Zakrzewski, J. L.
Article Title: Modern management of respiratory failure due to pulmonary mycoses following allogeneic hematopoietic stem-cell transplantation
Abstract: Pulmonary mycoses count among the most dangerous complications in allogeneic hematopoietic stem cell transplantation. Despite the establishment of antifungal chemoprophylaxis and empirical antifungal treatment, they frequently lead to respiratory failure and are still associated with an extraordinarily poor prognosis. However, the emergence of new antimycotics with alternative mechanisms of actions and decreased toxicity in combination with the development of new non culture-based diagnostic techniques may allow earlier, more aggressive and more effective antifungal treatment approaches. In addition, the optimized use of new technologies designed to augment spontaneous breathing efforts by patients, mechanical ventilation, as well as the advantages of early tracheostomy lead us to expect better outcomes in the treatment of respiratory failure due to pulmonary mycoses following allogeneic hematopoietic stem cell transplantation. © 2005 Wiley-Liss, Inc.
Keywords: transplantation, homologous; clinical trial; review; microscopy; drug efficacy; polymerase chain reaction; computer assisted tomography; liver toxicity; nephrotoxicity; antifungal agent; steroid; hematopoietic stem cell transplantation; risk factor; biopsy; hypokalemia; acute graft versus host disease; allogeneic hematopoietic stem cell transplantation; calcineurin inhibitor; tacrolimus; hallucination; visual disorder; tracheostomy; serology; caspofungin; fluconazole; cyclosporin; voriconazole; beta 1,3 glucan; x ray; itraconazole; respiratory insufficiency; artificial ventilation; respiratory failure; lung lavage; fungal dna; mechanical ventilation; amphotericin b lipid complex; fungus culture; positive end expiratory pressure; fungus antigen; invasive fungal infection; lung mycosis; amphotericin b; lung diseases, fungal; hematopoietic stem-cell transplantation; pulmonary mycosis; amphotericin b cholesterol sulfate; fungus antibody
Journal Title: American Journal of Hematology
Volume: 79
Issue: 2
ISSN: 0361-8609
Publisher: John Wiley & Sons, Inc.  
Date Published: 2005-06-01
Start Page: 158
End Page: 163
Language: English
DOI: 10.1002/ajh.20361
PUBMED: 15929105
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 24 October 2012" - "CODEN: AJHED" - "Source: Scopus"
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