Authors: | Pastores, S. M.; Papadopoulos, E.; Voigt, L.; Halpern, N. A. |
Article Title: | Diffuse alveolar hemorrhage after allogeneic hematopoietic stem-cell transplantation: Treatment with recombinant factor VIIa |
Abstract: | Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication that occurs in patients undergoing hematopoietic stem-cell transplantation (HSCT). Current management strategies are limited to corticosteroids, platelet transfusions, and mechanical ventilator support to treat acute respiratory failure. Recombinant factor VIIa (rFVIIa) is an approved agent for the treatment of bleeding in patients with hemophilia A or B and the presence of inhibitors. We report a case of DAH after allogeneic HSCT that failed standard therapy and was then successfully treated with rFVIIa. |
Keywords: | adult; treatment outcome; middle aged; antibiotic agent; prednisone; case report; doxorubicin; cancer combination chemotherapy; side effect; methotrexate; rituximab; antineoplastic agent; carboplatin; computer assisted tomography; etoposide; bleeding; tomography, x-ray computed; cyclophosphamide; vincristine; hematopoietic stem cell transplantation; ifosfamide; thiotepa; intensive care units; nonhodgkin lymphoma; thromboembolism; recombinant proteins; warfarin; brain metastasis; graft versus host reaction; postoperative infection; thorax radiography; corticosteroid; heart atrium fibrillation; rapamycin; diuretic agent; anticoagulant agent; lung hemorrhage; lung diseases; recombinant blood clotting factor 7a; hemorrhage; diffuse alveolar hemorrhage; factor vii; humans; human; male; priority journal; article; allogeneic hematopoietic stem-cell transplantation; recombinant factor viia |
Journal Title: | Chest |
Volume: | 124 |
Issue: | 6 |
ISSN: | 0012-3692 |
Publisher: | American College of Chest Physicians |
Date Published: | 2003-12-01 |
Start Page: | 2400 |
End Page: | 2403 |
Language: | English |
DOI: | 10.1016/S0012-3692(16)60407-5 |
PUBMED: | 14665531 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Export Date: 12 September 2014 -- Source: Scopus |