Diffuse alveolar hemorrhage after allogeneic hematopoietic stem-cell transplantation: Treatment with recombinant factor VIIa Journal Article


Authors: Pastores, S. M.; Papadopoulos, E.; Voigt, L.; Halpern, N. A.
Article Title: Diffuse alveolar hemorrhage after allogeneic hematopoietic stem-cell transplantation: Treatment with recombinant factor VIIa
Abstract: Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication that occurs in patients undergoing hematopoietic stem-cell transplantation (HSCT). Current management strategies are limited to corticosteroids, platelet transfusions, and mechanical ventilator support to treat acute respiratory failure. Recombinant factor VIIa (rFVIIa) is an approved agent for the treatment of bleeding in patients with hemophilia A or B and the presence of inhibitors. We report a case of DAH after allogeneic HSCT that failed standard therapy and was then successfully treated with rFVIIa.
Keywords: adult; treatment outcome; middle aged; antibiotic agent; prednisone; case report; doxorubicin; cancer combination chemotherapy; side effect; methotrexate; rituximab; antineoplastic agent; carboplatin; computer assisted tomography; etoposide; bleeding; tomography, x-ray computed; cyclophosphamide; vincristine; hematopoietic stem cell transplantation; ifosfamide; thiotepa; intensive care units; nonhodgkin lymphoma; thromboembolism; recombinant proteins; warfarin; brain metastasis; graft versus host reaction; postoperative infection; thorax radiography; corticosteroid; heart atrium fibrillation; rapamycin; diuretic agent; anticoagulant agent; lung hemorrhage; lung diseases; recombinant blood clotting factor 7a; hemorrhage; diffuse alveolar hemorrhage; factor vii; humans; human; male; priority journal; article; allogeneic hematopoietic stem-cell transplantation; recombinant factor viia
Journal Title: Chest
Volume: 124
Issue: 6
ISSN: 0012-3692
Publisher: American College of Chest Physicians  
Date Published: 2003-12-01
Start Page: 2400
End Page: 2403
Language: English
DOI: 10.1016/S0012-3692(16)60407-5
PUBMED: 14665531
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Neil A Halpern
    136 Halpern
  2. Stephen Pastores
    190 Pastores
  3. Louis Pierre-Paul Voigt
    72 Voigt