Engineering refinements to overcome default nuclide regulatory constraints Journal Article


Authors: Finn, R.; Capitelli, P.; Sheh, Y.; Lom, C.; Graham, M.; St. Germain, J.
Article Title: Engineering refinements to overcome default nuclide regulatory constraints
Abstract: The "classical" positron emitting radionuclides include oxygen-15, nitrogen-13 and carbon-11 which possess unique properties for medical imaging. They are radionuclides of the fundamental elements of biological matter. They each possess short half-lives which allow their use in designed radiotracers for clinical investigations with minimal risk and they are readily able to be produced in sufficient activities by low energy nuclear reactions. At present several accelerator manufacturers offer production packages for these radionuclides emphasizing targetry with consideration of the cyclotron extracted energies for nuclide production and on-line chemistry systems for the continuous production of specific precursors or radiotracers. Following the installation and acceptance of the MSKCC TR 19/9 Cyclotron, our experience with the procured chemistry module for the preparation of oxygen-15 labeled water has forced us to examine the design and the operation of the synthetic unit with a view toward the state of New York's regulations addressing the environmental pollution from radioactive materials. The chemistry module was refined with subtle modifications to the chemistry procedure/unit and our experience with the unit is presented as an example of our approach to insure regulatory compliance. © 2005 Elsevier B.V. All rights reserved.
Keywords: positron emission tomography; blood; medical imaging; targets; radioisotopes; particle accelerators; cyclotrons; cerebral blood flow; regulatory compliance; oxygen-15; radioactive materials; nuclide production
Journal Title: Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume: 241
Issue: 1-4
ISSN: 0168-583X
Publisher: Elsevier B.V.  
Date Published: 2005-12-01
Start Page: 665
End Page: 669
Language: English
DOI: 10.1016/j.nimb.2005.07.238
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 24 October 2012" - "CODEN: NIMBE" - "Source: Scopus"
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MSK Authors
  1. Ronald D Finn
    278 Finn
  2. Yiauchung Sheh
    9 Sheh
  3. Calvin A Lom
    5 Lom
  4. Martin C Graham
    49 Graham
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