Cyclotron production and potential clinical application of Iodine-124 labeled radiotracers Conference Paper
| Authors: | Finn, R.; Balatoni, J.; Kothari, P.; Pentlow, K.; Sheh, Y.; Lom, C.; Dahl, J.; Eckelman, W.; Plascjak, P.; Adams, H. R.; Larson, S. M. |
| Title: | Cyclotron production and potential clinical application of Iodine-124 labeled radiotracers |
| Conference Title: | The CAARI 2000: Sixteenth International Conference on the Application of Accelerators in Research and Industry |
| Abstract: | Positron emission tomography (PET) is a dynamic molecular imaging technique applicable to clinical research, drug development as well as clinical diagnoses. The potential for PET is derived from specificity of the radiotracers and radioligands that are synthesized to monitor the biochemical or physiological processes. Further developments will depend on an increasing availability of unique radiotracers. Iodine-124, a radionuclide that has potential for both diagnostic and therapeutic applications, possesses a half-life of 4.18 days and decays by positron emission (23.3%) and electron capture (76.7%). The preparation of this radionuclide via the Te-124(p,n)I-124 nuclear reaction is described as well as chemistry associated with the preparation of specific radiotracers and radiopharmaceuticals incorporating iodine-124 at Memorial Sloan-Kettering Cancer Center. |
| Keywords: | colchicine; cells; i-124; human-tumor |
| Journal Title | AIP Conference Proceedings |
| Volume: | 576 |
| Conference Dates: | 2000 Nov 1-5 |
| Conference Location: | Denton, TX |
| ISBN: | 0094-243X |
| Publisher: | American Institute of Physics |
| Location: | Melville |
| Date Published: | 2001-07-12 |
| Start Page: | 849 |
| End Page: | 852 |
| Language: | English |
| ACCESSION: | WOS:000172263600202 |
| PROVIDER: | wos |
| DOI: | 10.1063/1.1395436 |
| Notes: | Proceedings Paper -- Presented at the 16th International Conference on the Application of Accelerators in Research and Industry -- 2000 Nov 01-05 -- Denton, TX -- Natl Sci Fdn, US DOE, Amer Phys Soc, Div Nucl Phys -- 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA -- Source: Wos |
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