Improved yields of iodine-124 from the enriched tellurium-124 dioxide/aluminum oxide target Conference Paper


Authors: Finn, R. D.; Qiao, J.; Nacca, A.; Sheh, Y.; Lom, C.; Balatoni, J.; Cai, S.; Bornmann, W.; Pentlow, K.
Title: Improved yields of iodine-124 from the enriched tellurium-124 dioxide/aluminum oxide target
Conference Title: 17th International Conference on the Application of Accelerators in Research and Industry
Abstract: The escalating clinical application of Positron Emission Tomography results from the novel radiotracers which are available to monitor specific biochemical or physiologic processes. Future developments of the technique will require an increasing availability of additional unique radioligands and radionuclides. Iodine-124, a radionuclide whose potential for both diagnostic and therapeutic applications is widely recognized, has been prepared at Memorial Sloan-Kettering Cancer Center on a weekly basis for several years (1). With its characteristic 4.18 day half life and complex decay scheme (2) which includes positron emission (22.0 ± 0.5%) and electron capture (78 ± 0.5%), this radionuclide has been shown to be appropriate for radiotracers describing slow physiologic processes with the clearance of non-specific radioactivity. The refinements and modifications being engineered into the cyclotron target system to increase the absolute yield of recoverable radioactivity from each irradiation and its chemical processing of the reusable solid target matrix are described. © 2003 American Institute of Physics.
Keywords: positron emission tomography; radiation; physiology; radioactivity; radioactive tracers; radioisotopes; positrons; clinical application; chemical modification; iodine; positron emission; tellurium compounds; therapeutic application; chemical industry; computer software reusability; industrial research; chemical processing; electron capture; solid targets; specific radioactivity; target systems
Journal Title AIP Conference Proceedings
Volume: 680
Conference Dates: 2002 Nov 12-16
Conference Location: Denton, TX
ISBN: 0094-243X
Publisher: American Institute of Physics  
Date Published: 2003-08-26
Start Page: 1121
End Page: 1124
Language: English
DOI: 10.1063/1.1619905
PROVIDER: scopus
DOI/URL:
Notes: Conference Paper -- Export Date: 1 March 2018 -- Source: Scopus
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Citation Impact
MSK Authors
  1. Angelo Nacca
    6 Nacca
  2. William Bornmann
    112 Bornmann
  3. Ronald D Finn
    278 Finn
  4. Shangde Cai
    42 Cai
  5. Yiauchung Sheh
    9 Sheh
  6. Keith S Pentlow
    63 Pentlow
  7. Calvin A Lom
    5 Lom
  8. Jing Qiao
    2 Qiao