Unconventional nuclides for radiopharmaceuticals Journal Article
| Authors: | Holland, J. P.; Williamson, M. J.; Lewis, J. S. |
| Article Title: | Unconventional nuclides for radiopharmaceuticals |
| Abstract: | Rapid and widespread growth in the use of nuclear medicine for both diagnosis and therapy of disease has been the driving force behind burgeoning research interests in the design of novel radiopharmaceuticals. Until recently, the majority of clinical and basic science research has focused on the development of 11C-, 13N-, 15O-, and 18F-radiopharmaceuticals for use with positron emission tomography (PET) and 99mTc-labeled agents for use with single-photon emission computed tomography (SPECT). With the increased availability of small, low-energy cyclotrons and improvements in both cyclotron targetry and purifi cation chemistries, the use of "nonstandard" radionuclides is becoming more prevalent. This brief review describes the physical characteristics of 60 radionuclides, including β+ , β- , γ-ray, and a-particle emitters, which have the potential for use in the design and synthesis of the next generation of diagnostic and/or radiotherapeutic drugs. As the decay processes of many of the radionuclides described herein involve emission of high-energy γ-rays, relevant shielding and radiation safety issues are also considered. In particular, the properties and safety considerations associated with the increasingly prevalent PET nuclides 64Cu, 68Ga, 86Y, 89Zr, and 124I are discussed. © 2010 BC Decker Inc. |
| Keywords: | review; positron emission tomography; methodology; radiopharmaceuticals; radiotherapy; chemistry; diagnostic agent; computerized tomography; diagnosis; positron-emission tomography; radiopharmaceutical agent; ionizing radiation; radiation, ionizing; nuclear medicine; radiometry; radioisotope; radiation safety; single photon emission computer tomography; radioisotopes; zirconium; cyclotrons; tomography, emission-computed, single-photon; basic science; decay process; driving forces; high energy; low energies; physical characteristics; safety considerations; targetry; gallium; radiation shielding; single photon emission computed tomography |
| Journal Title: | Molecular Imaging |
| Volume: | 9 |
| Issue: | 1 |
| ISSN: | 1535-3508 |
| Publisher: | Sage Publications, Inc. |
| Date Published: | 2010-02-01 |
| Start Page: | 1 |
| End Page: | 20 |
| Language: | English |
| DOI: | 10.2310/7290.2010.00008 |
| PUBMED: | 20128994 |
| PROVIDER: | scopus |
| PMCID: | PMC4962336 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 20 April 2011" - "Source: Scopus" |
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