Polysialic acid-induced plasticity reduces neuropathic insult to the central nervous system Journal Article

   


Authors: El-Maarouf, A. ; Kolesnikov, Y.; Pasternak, G.; Rutishauser, U.
Article Title: Polysialic acid-induced plasticity reduces neuropathic insult to the central nervous system
Abstract: Under chronic conditions of neuropathic pain, nociceptive C terminals are lost from their target region in spinal lamina II, leading to reduced thermal hyperalgesia. This region of the spinal cord expresses high levels of polysialic acid (PSA), a cell surface carbohydrate known to weaken cell-cell interactions and promote plasticity. Experimental removal of PSA from the spinal cord exacerbates hyperalgesia and results in retention of C terminals, whereas it has no effect on plasticity of touch Aβ fibers and allodynia. We propose that expression of PSA at this stress pathway relay point could serve to protect central circuitry from chronic sensory overload. © 2005 by The National Academy of Sciences of the USA.
Keywords: controlled study; protein phosphorylation; histopathology; nonhuman; mouse; animals; mice; animal tissue; pain; animal experiment; animal model; histological techniques; central nervous system; mice, inbred strains; nerve cell adhesion molecule; polysialic acid; nerve cell plasticity; chronic pain; neuroplasticity; analysis of variance; cell interaction; neuropathic pain; hyperalgesia; sialic acids; neuronal plasticity; glycoside hydrolases; animal behavior; neural cell adhesion molecule; posterior horn cells; nerve fibers, unmyelinated
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 102
Issue: 32
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 2005-08-09
Start Page: 11516
End Page: 11520
Language: English
DOI: 10.1073/pnas.0504718102
PUBMED: 16055555
PROVIDER: scopus
PMCID: PMC1183577
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-23844468768&partnerID=40&md5=8f00798e95e9cb123b34fb068f7b8923
Notes: --- - "Cited By (since 1996): 16" - "Export Date: 24 October 2012" - "CODEN: PNASA" - "Source: Scopus"
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MSK Authors
  1. Yuri Alexei Kolesnikov
    34 Kolesnikov
  2. Urs S Rutishauser
    70 Rutishauser
  3. Abderrahman El Maarouf
    22 El Maarouf
  4. Gavril W Pasternak
    414 Pasternak
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