Neural cell adhesion molecule and its polysialic acid moiety exhibit opposing and linked effects on neuropathic hyperalgesia Journal Article

   


Authors: El-Maarouf, A. ; Kolesnikov, Y.; Pasternak, G.; Rutishauser, U.
Article Title: Neural cell adhesion molecule and its polysialic acid moiety exhibit opposing and linked effects on neuropathic hyperalgesia
Abstract: Spinal lamina II, where nociceptive C-fibers terminate, expresses high amounts of the polysialylated form of neural cell adhesion molecule (PSA-NCAM). While enzymatic removal of the PSA moiety from NCAM did not affect normal sensitivity to thermal stimuli, it exacerbated nerve injury-induced neuropathic hyperalgesia. The genetic removal of the NCAM core protein also did not alter thermal sensitivity. However in the presence of a peripheral nerve injury, NCAM-null mutants exhibited a complete suppression of thermal hyperalgesia. This strong NCAM mutant phenotype appears to involve the long form of NCAM's cytoplasmic domain, in that it is duplicated by selective genetic deletion of the NCAM-180 isoform. PSA appears therefore to provide a mechanism for modulation of chronic sensory overload, by means of attenuation of the activity of the NCAM-180 isoform, which reduces nociceptive transmission. © 2011 Elsevier Inc.
Keywords: immunohistochemistry; controlled study; protein expression; gene deletion; nonhuman; protein domain; protein function; protein localization; animal cell; mouse; phenotype; animal tissue; molecular dynamics; animal experiment; animal model; wild type; nerve cell adhesion molecule; polysialic acid; chronic pain; molecular interaction; protein determination; carbohydrate analysis; hyperalgesia; nociception; thermal hyperalgesia; molecular pathology; ncam; peripheral nerve injury; heat sensitivity
Journal Title: Experimental Neurology
Volume: 233
Issue: 2
ISSN: 0014-4886
Publisher: Elsevier Inc.  
Date Published: 2012-02-01
Start Page: 866
End Page: 870
Language: English
DOI: 10.1016/j.expneurol.2011.12.017
PROVIDER: scopus
PUBMED: 22200540
PMCID: PMC4041112
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84856540317&partnerID=40&md5=47aa0a8ebec3eae2020f51c26c9c860a
Notes: --- - "Export Date: 1 March 2012" - "CODEN: EXNEA" - "Source: Scopus"
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MSK Authors
  1. Yuri Alexei Kolesnikov
    34 Kolesnikov
  2. Urs S Rutishauser
    70 Rutishauser
  3. Abderrahman El Maarouf
    22 El Maarouf
  4. Gavril W Pasternak
    414 Pasternak
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