Removal of polysialylated neural cell adhesion molecule increases morphine analgesia and interferes with tolerance in mice Journal Article
| Authors: | El-Maarouf, A. ; Kolesnikov, Y.; Pasternak, G.; Rutishauser, U. |
| Article Title: | Removal of polysialylated neural cell adhesion molecule increases morphine analgesia and interferes with tolerance in mice |
| Abstract: | Neurons that express high levels of polysialylated neural cell adhesion molecule (PSA-NCAM) in adult spinal substantia gelatinosa also express the μ-opioid receptor. While PSA removal from NCAM by spinal intrathecal injection of endoneuraminidase-N (endo-N) did not detectably change opioid receptor expression, morphine-induced analgesia was significantly increased. This analgesic strengthening was detected as early as 15 min after endo-N treatment and persisted for at least 7 days. In addition, the tolerance that develops with chronic morphine treatment was overcome in the absence of PSA. Interestingly, the same effects on analgesia and tolerance were also produced by selective deletion of the NCAM-180 isoform. © 2011 Elsevier B.V. All rights reserved. |
| Keywords: | pain; opiate; polysialic acid; tolerance; ncam; antinociceptive |
| Journal Title: | Brain Research |
| Volume: | 1404 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2011-08-02 |
| Start Page: | 55 |
| End Page: | 62 |
| Language: | English |
| DOI: | 10.1016/j.brainres.2011.06.021 |
| PROVIDER: | scopus |
| PUBMED: | 21704981 |
| PMCID: | PMC4041115 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 August 2011" - "CODEN: BRREA" - "Source: Scopus" |
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70Rutishauser -
22
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414Pasternak
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