Reorganization of dorsal root ganglion neurons following chronic sciatic nerve constriction injury: Correlation with morphine and lidocaine analgesia Journal Article
| Authors: | Kolesnikov, Y.; El-Maarouf, A. ; Rutishauser, U.; Pasternak, G. |
| Article Title: | Reorganization of dorsal root ganglion neurons following chronic sciatic nerve constriction injury: Correlation with morphine and lidocaine analgesia |
| Abstract: | Chronic constriction injury of the sciatic nerve is an animal model for neuropathic pain. In this model, the analgesic potency of systemic morphine was significantly diminished in nerve-injured mice (ED50 19.4 mg/kg) compared with sham-operated mice (ED50 3.3 mg/kg) using a unilateral hot plate withdrawal test, with a similar reduction in sensitivity of intrathecal morphine. The sciatic nerve injury resulted in a reorganization of the dorsal root ganglion (DRG) neurons. Immunohistochemically, the chronic constriction injury triggered a withdrawal of C-fibers from the ipsilateral dorsal horn of the spinal cord. Although A-β terminals centrally sprouted into Lamina II of the dorsal horn of the spinal cord, the peripheral A-β fibers in the skin retracted from the epidermis to deeper layers of the dermis. To explore the functional significance of these dermal changes, we examined the topical morphine and lidocaine analgesia following chronic sciatic nerve constriction. Both morphine and lidocaine retained topical activity following chronic sciatic nerve injury, but their analgesic dose-response curves were shifted to the right when compared to sham-operated mice. Thus, the chronic nerve constriction injury model is associated with pathological changes in distribution of the central and peripheral axons of the dorsal root ganglion neurons that correspond to a decreased pharmacological sensitivity to topical analgesic agents. © 2007 Elsevier B.V. All rights reserved. |
| Keywords: | immunohistochemistry; controlled study; area under the curve; dose response; drug potentiation; nonhuman; mouse; animals; mice; animal tissue; pain; animal experiment; animal model; neurons; drug potency; mice, inbred icr; skin; drug therapy, combination; nerve cell plasticity; nerve injury; morphine; analgesics, opioid; opioid; lidocaine; anesthetics, local; drug sensitivity; analgesia; neuropathic pain; mu opiate receptor; receptors, opioid, mu; hyperalgesia; naloxone; hot plate test; plasticity; spinal ganglion; sciatic nerve; ganglia, spinal; spinal cord dorsal horn; nerve sprouting; nerve fibers, myelinated; local anesthetics; topical analgesia; afferent nerve group 1; nerve compression; nerve fiber c; constriction; nerve fibers, unmyelinated; sciatic neuropathy |
| Journal Title: | European Journal of Pharmacology |
| Volume: | 568 |
| Issue: | 1-3 |
| ISSN: | 0014-2999 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2007-07-30 |
| Start Page: | 124 |
| End Page: | 133 |
| Language: | English |
| DOI: | 10.1016/j.ejphar.2007.04.045 |
| PUBMED: | 17543299 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: EJPHA" - "Source: Scopus" |
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34Kolesnikov -
70Rutishauser -
22
El Maarouf -
414Pasternak
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