The evolution of a genetic locus encoding small serine proteinase inhibitors Journal Article

   

Authors:	Clauss, A.; Lilja, H.; Lundwall, Å
Article Title:	The evolution of a genetic locus encoding small serine proteinase inhibitors
Abstract:	We previously identified a locus on human chromosome 20 that encompasses 14 genes of postulated WFDC-type proteinase inhibitors with a potential role in innate immunity. In an extended study, homologous loci are here described on mouse chromosome 2, rat chromosome 3, and dog chromosome 24. As in humans, the murine and canine loci are divided into two sub-loci separated by 0.2 Mb. The majority of genes are conserved in all species, but there are also species-specific gains and losses of genes, e.g., several duplications have yielded four SLPI genes in the rat and, most surprisingly, there is no murine elafin gene. Two human pseudogenes were identified due to the discovery of functional rodent genes. The conservation of different WFDC domains varies considerably, and it is hypothesized that this reflects a dual role of WFDC inhibitors in natural immunity, which is directed both against microbes and proinflammatory cells. © 2005 Elsevier Inc. All rights reserved.
Keywords:	genetic analysis; protein domain; animals; mice; inflammation; gene locus; evolution; evolution, molecular; amino acid sequence; molecular sequence data; species specificity; dogs; serine proteinase inhibitor; kallikrein; murinae; gene duplication; base sequence; innate immunity; rats; rodentia; immunity; sequence homology, nucleic acid; epididymis; chromosome loss; polymorphism, genetic; chromosome 2; quantitative trait loci; chromosome mapping; genetic identification; chromosome 3; microorganism; serine proteinase inhibitors; canis familiaris; pseudogene; protease inhibitor; milk proteins; genital tract; respiratory tract; serine protease; wfdc; elafin
Journal Title:	Biochemical and Biophysical Research Communications
Volume:	333
Issue:	2
ISSN:	0006-291X
Publisher:	Elsevier Science, Inc.
Date Published:	2005-07-29
Start Page:	383
End Page:	389
Language:	English
DOI:	10.1016/j.bbrc.2005.05.125
PUBMED:	15950183
PROVIDER:	scopus
PMCID:	PMC1939935
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-20544464873&partnerID=40&md5=0ba4a9867ee314b4f67dcba1547d2e97
Notes:	--- - "Cited By (since 1996): 39" - "Export Date: 24 October 2012" - "CODEN: BBRCA" - "Molecular Sequence Numbers: GENBANK: AY541526, AY542486, AY542487, AY542488, AY542489, AY669505, AY669506, AY757956;" - "Source: Scopus"

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