The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical Journal Article
| Authors: | Koehne, C. F.; Lazo, P. A.; Alves, K.; Lee, J. S.; Tsichlis, P. N.; O'Donnell, P. V. |
| Article Title: | The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical |
| Abstract: | Mlvi-1 defines a locus of proviral integration in rat thymomas induced by Moloney murine leukemia virus. pvt-1/Mis-1 represents an independently identified locus which becomes rearranged either by chromosomal translocation in murine plasmacytomas or by provirus insertion in retrovirus-induced murine and rat thymic lymphomas. Although it had been claimed that pvt-1/Mis-1 and Mlvi-1 represent two different loci, we present here evidence showing that they are identical. This finding demonstrates the need for rigorous characterization of any newly identified common regions of integration in retrovirus-induced neoplasms. |
| Keywords: | nonhuman; animal; mice; carcinogenesis; cell culture; lymphoma; rats; thymoma; moloney leukemia oncovirus; moloney murine leukemia virus; cell transformation, viral; chromosome mapping; regulatory sequences, nucleic acid; southern blotting; locus; restriction mapping; dna probes; blotting, southern; priority journal; provirus; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Journal of Virology |
| Volume: | 63 |
| Issue: | 5 |
| ISSN: | 0022-538X |
| Publisher: | American Society for Microbiology |
| Date Published: | 1989-05-01 |
| Start Page: | 2366 |
| End Page: | 2369 |
| Language: | English |
| PUBMED: | 2704080 |
| PROVIDER: | scopus |
| PMCID: | PMC250659 |
| DOI: | 10.1128/jvi.63.5.2366-2369.1989 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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