Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers Journal Article
| Authors: | Maser, R. S.; Choudhury, B.; Campbell, P. J.; Feng, B.; Wong, K. K.; Protopopov, A.; O'Neil, J.; Gutierrez, A.; Ivanova, E.; Perna, I.; Lin, E.; Mani, V.; Jiang, S.; McNamara, K.; Zaghlul, S.; Edkins, S.; Stevens, C.; Brennan, C.; Martin, E. S.; Wiedemeyer, R.; Kabbarah, O.; Nogueira, C.; Histen, G.; Aster, J.; Mansour, M.; Duke, V.; Foroni, L.; Fielding, A. K.; Goldstone, A. H.; Rowe, J. M.; Wang, Y. A.; Look, A. T.; Stratton, M. R.; Chin, L.; Futreal, P. A.; DePinho, R. A. |
| Article Title: | Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers |
| Abstract: | Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread recurrent amplifications and deletions targeting loci syntenic to those not only in human T-ALL but also in diverse human haematopoietic, mesenchymal and epithelial tumours. These results indicate that murine and human tumours experience common biological processes driven by orthologous genetic events in their malignant evolution. The highly concordant nature of genomic events encourages the use of genomically unstable murine cancer models in the discovery of biological driver events in the human oncogenome. ©2007 Nature Publishing Group. |
| Keywords: | gene deletion; mutation; nonhuman; chromosome; mouse; animals; mice; gene; mus; gene amplification; animal experiment; animal model; gene locus; acute lymphoblastic leukemia; carcinogenesis; cancer genetics; lymphoma, t-cell; conserved sequence; genetic engineering; pten phosphohydrolase; lymphoma; murinae; chromosomal instability; genome; rodent; chromosome aberrations; tumor; tumor gene; t cell leukemia; modeling; pten gene; assessment method; fbxw7 gene; leukemia, t-cell, acute; synteny |
| Journal Title: | Nature |
| Volume: | 447 |
| Issue: | 7147 |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-06-21 |
| Start Page: | 966 |
| End Page: | 971 |
| Language: | English |
| DOI: | 10.1038/nature05886 |
| PUBMED: | 17515920 |
| PROVIDER: | scopus |
| PMCID: | PMC2714968 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 124" - "Export Date: 17 November 2011" - "CODEN: NATUA" - "Source: Scopus" |
