Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma Journal Article
| Authors: | Cao, W.; Cai, L.; Rao, J. Y.; Pantuck, A.; Lu, M. L.; Dalbagni, G.; Reuter, V.; Scher, H.; Cordon-Cardo, C.; Figlin, R. A.; Belldegrun, A.; Zhang, Z. F. |
| Article Title: | Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma |
| Abstract: | BACKGROUND. Although cigarette smoking is considered a major risk factor for bladder carcinoma, little is known about the interaction between metabolic genes such as glutathione-S-transferase P1 and tobacco smoking in this process. GSTP1 may play a role in detoxification of tobacco-related carcinogens. METHODS. In this case-control study of 145 cases with bladder carcinoma (male: female = 7.5:1) and 170 noncancer controls (male:female = 3.7:1), the relation between genetic polymorphisms of GSTP1 and susceptibility to bladder carcinoma was investigated and the gene-environment interaction between tobacco smoking and GSTP1 polymorphism was evaluated. Epidemiological data were collected for all cases and controls by a standard questionnaire. Polymorphisms of GSTP1 were measured by polymerase chain reaction-restriction fragment length polymorphism. The logistic regression model in SAS was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS. Cigarette smoking was confirmed as a risk factor of bladder carcinoma with an OR of 3.1 (95% CI: 1.7-5.9) after controlling for potential confounding factors. The OR for pack-years of smoking as a continuous variable was 2.4 (95% CI: 2.0-2.8). The ORs were 7.6 (95% CI: 1.18-49.51) for isoleucine/valine (Ile/Val) and 6.5 (95% CI: 1.01-41.56) for Ile/Ile when the homozygous Val/Val was considered as comparison group after adjusting for age, gender, race, and education. The adjusted OR for interaction between smoking and the GSTP1 (any Ile genotype) was 11.42 (95% CI: 0.53-248.15). CONCLUSIONS. The results indicate that the Ile 105 allele is associated with an increased risk of bladder carcinoma and suggest that individuals who smoke and possess the Ile allele might be at increased risk for bladder carcinoma. © 2005 American Cancer Society. |
| Keywords: | adult; controlled study; human tissue; middle aged; unclassified drug; major clinical study; case control study; case-control studies; cigarette smoking; cancer risk; patient selection; polymerase chain reaction; allele; cancer susceptibility; genotype; odds ratio; smoking; urinary bladder neoplasms; homozygosity; dna, neoplasm; glutathione transferase; isoleucine; detoxification; bladder carcinoma; polymorphism, genetic; alcohol drinking; valine; genetic polymorphism; pcr; polymorphism; glutathione transferase p1; restriction fragment length polymorphism; polymorphism, restriction fragment length; genotype environment interaction; gene-environment; gstp1; glutathione s-transferase pi |
| Journal Title: | Cancer |
| Volume: | 104 |
| Issue: | 11 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2005-12-01 |
| Start Page: | 2400 |
| End Page: | 2408 |
| Language: | English |
| DOI: | 10.1002/cncr.21446 |
| PUBMED: | 16240451 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 28" - "Export Date: 24 October 2012" - "CODEN: CANCA" - "Source: Scopus" |
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320Dalbagni -
612Cordon-Cardo -
23
Lu -
1199Reuter -
1111Scher
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