CYP1A1 and GSTM1 polymorphisms and oral cancer risk Journal Article


Authors: Park, J. Y.; Muscat, J. E.; Ren, Q.; Schantz, S. P.; Harwick, R. D.; Stern, J. C.; Pike, V.; Richie Jr, J. P.; Lazarus, P.
Article Title: CYP1A1 and GSTM1 polymorphisms and oral cancer risk
Abstract: The importance of both the CYP1A1 exon 7 (ile:val) and GSTM1 (0/0) polymorphisms in oral cancer susceptibility was assessed by examining polymorphic prevalences in 135 patients with oral cancer and 135 noncancer controls frequency-matched by age at diagnosis (± 5 years), race, sex, and institute of patient recruitment. The prevalence of the GSTM1 (0/0) genotype was approximately 51% in both cases and controls. The prevalence of the CYP1A1 (ile:val) polymorphism [including both the (ile/val) and (val/val) genotypes] was significantly higher in cases as compared to controls (17.6% versus 7.6%, respectively; crude odds ratio, 2.6; confidence interval, 1.2- 5.7). No association was observed between polymorphic prevalence and levels of smoking or alcohol consumption in cases. These results suggest that the GSTM1 null genotype is not associated with oral cancer risk. These results also suggest that individuals with the CYP1A1 exon 7 ile:val polymorphism are at increased risk for oral cancer, and that this risk may not be influenced by differences in exposure to tobacco smoke.
Keywords: adult; controlled study; aged; middle aged; major clinical study; case-control studies; carcinoma, squamous cell; laryngeal neoplasms; cancer risk; polymerase chain reaction; cancer susceptibility; prevalence; genotype; risk factors; smoking; genetic susceptibility; glutathione transferase; genetic risk; alcohol consumption; european continental ancestry group; polymorphism, genetic; mouth neoplasms; mouth cancer; alcohol drinking; cytochrome p-450 cyp1a1; dna polymorphism; humans; human; male; female; priority journal; article
Journal Title: Cancer Epidemiology Biomarkers and Prevention
Volume: 6
Issue: 10
ISSN: 1055-9965
Publisher: American Association for Cancer Research  
Date Published: 1997-10-01
Start Page: 791
End Page: 797
Language: English
PUBMED: 9332761
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 17 March 2017 -- Source: Scopus
Citation Impact
MSK Authors
  1. Stimson P Schantz
    113 Schantz