GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population Journal Article
| Authors: | Setiawan, V. W.; Zhang, Z. F.; Yu, G. P.; Lu, Q. Y.; Li, Y. L.; Lu, M. L.; Wang, M. R.; Guo, C. H.; Yu, S. Z.; Kurtz, R. C.; Hsieh, C. C. |
| Article Title: | GSTP1 polymorphisms and gastric cancer in a high-risk Chinese population |
| Abstract: | Objectives: In a population-based case-control study in Yangzhong, China, we investigated the relationship between genetic polymorphisms of GSTP1 and susceptibility to gastric cancer and its premalignant lesion, chronic gastritis. The possible gene-gene interactions between GSTP1 polymorphisms and GSTM1, GSTT1 genes were explored. Methods: Epidemiologic data were collected by standard questionnaire from 133 gastric cancer cases, 166 chronic gastritis cases, and 433 cancer-free population controls. Blood samples for Helicobacter pylori and molecular marker assays were collected from 84 gastric cancer cases, 146 chronic gastritis, and 429 population controls. GSTP1 polymorphisms were determined by the PCR-RFLP method and H. pylori infection was measured by the ELISA method. Associations between certain GSTP1 genotypes and both gastric cancer and chronic gastritis were assessed by odds ratios (ORs) and 95% confidence intervals (CIs) derived from logistic regression. Results: The distributions of three GSTP1 genotypes, Ile/Ile, Ile/Val, and Val/Val, were similar in gastric cancer cases, chronic gastritis, and controls. After adjusting for age, gender, education, body mass index, pack-year of smoking, alcohol drinking, H. pylori infection, salt and fruit intakes, the adjusted ORs of Val/Val were 1.3 (95% CI: 0.1-11.2) for gastric cancer and 0.9 (95% CI: 0.2-4.8) for chronic gastritis. Combining the Val alleles (Val/Val and Ile/Val) into one group, no association was observed between GSTP1 and both gastric cancer and chronic gastritis. In addition, the allelism at the GSTP1 locus did not increase gastric cancer and chronic gastritis risks associated with the GSTM1 or GSTT1 genotypes. Conclusion: Our data suggest that the GSTP1 genotype seems not to be associated with the risk of gastric cancer and chronic gastritis in a high-risk Chinese population. |
| Keywords: | adult; controlled study; unclassified drug; major clinical study; case-control studies; cigarette smoking; cancer risk; polymerase chain reaction; cancer susceptibility; disease association; logistic models; prevalence; genetic association; genotype; odds ratio; risk factors; enzyme linked immunosorbent assay; chronic disease; questionnaire; statistical analysis; glutathione transferase; stomach cancer; high risk population; stomach neoplasms; polymorphism, genetic; helicobacter infections; helicobacter pylori; drinking behavior; isoenzymes; genetic polymorphism; genetic epidemiology; china; gastric cancer; glutathione transferase p1; restriction fragment length polymorphism; gstp1; glutathione s-transferase pi; chronic gastritis; humans; human; male; female; priority journal; article |
| Journal Title: | Cancer Causes & Control |
| Volume: | 12 |
| Issue: | 8 |
| ISSN: | 0957-5243 |
| Publisher: | Springer |
| Date Published: | 2001-10-01 |
| Start Page: | 673 |
| End Page: | 681 |
| Language: | English |
| DOI: | 10.1023/a:1011261602940 |
| PUBMED: | 11562107 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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