Elaborating polarity: PAR proteins and the cytoskeleton Journal Article


Authors: Nance, J.; Zallen, J. A.
Article Title: Elaborating polarity: PAR proteins and the cytoskeleton
Abstract: Cell polarity is essential for cells to divide asymmetrically, form spatially restricted subcellular structures and participate in three-dimensional multicellular organization. PAR proteins are conserved polarity regulators that function by generating cortical landmarks that establish dynamic asymmetries in the distribution of effector proteins. Here, we review recent findings on the role of PAR proteins in cell polarity in C. elegans and Drosophila, and emphasize the links that exist between PAR networks and cytoskeletal proteins that both regulate PAR protein localization and act as downstream effectors to elaborate polarity within the cell.
Keywords: drosophila; cell polarity; cytoskeleton; c. elegans; epithelial cell; par proteins
Journal Title: Development
Volume: 138
Issue: 5
ISSN: 0950-1991
Publisher: Company of Biologists  
Date Published: 2011-03-01
Start Page: 799
End Page: 809
Language: English
DOI: 10.1242/dev.053538
PROVIDER: scopus
PMCID: PMC3035085
PUBMED: 21303844
DOI/URL:
Notes: --- - "Export Date: 4 March 2011" - "CODEN: DEVPE" - "Source: Scopus"
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MSK Authors
  1. Jennifer A Zallen
    39 Zallen